细胞外囊泡在临床实验室中的应用前景
Extracellular Vesicles Move Toward Use in Clinical Laboratories.
作者信息
Strotman Lindsay N, Linder Mark W
机构信息
PGXL Technologies, 201 East Jefferson Street, Suite 306, Louisville, KY 40202, USA; Department of Engineering, University of Louisville, Louisville, Kentucky, USA.
PGXL Technologies, 201 East Jefferson Street, Suite 306, Louisville, KY 40202, USA; Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine, 511 S Floyd Street, MDR Building, Room 204, Louisville, KY 40292, USA.
出版信息
Clin Lab Med. 2016 Sep;36(3):587-602. doi: 10.1016/j.cll.2016.05.004.
Extracellular vesicles (EVs) are membranous particles found in a variety of biofluids that encapsulate molecular information from the cell, which they originate from. This rich source of information that is easily obtained can then be mined to find diagnostic biomarkers. This article explores the current biological understanding of EVs and specific methods to isolate and analyze them. A case study of a company leading the charge in using EVs in diagnostic assays is provided.
细胞外囊泡（EVs）是在多种生物流体中发现的膜性颗粒，它们封装了源自其起源细胞的分子信息。这种易于获取的丰富信息源随后可被挖掘以寻找诊断生物标志物。本文探讨了目前对细胞外囊泡的生物学理解以及分离和分析它们的具体方法。还提供了一个在诊断检测中率先使用细胞外囊泡的公司的案例研究。
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