Manoharan A, Barla G S, Peter R, Sugumar M, Mathai D
Pushpagiri Research Center, Pushpagiri Institute of Medical Sciences and Research Center, Thiruvalla, Kerala, India.
Department of Medicine, Benjamin M Pulimood Laboratories for Infection, Immunity and Inflammation, Christian Medical College, Vellore, Tamil Nadu, India.
Indian J Med Microbiol. 2016 Jul-Sep;34(3):359-61. doi: 10.4103/0255-0857.188350.
In this study, we evaluated the coexistence of extended-spectrum beta-lactamases (ESBL), AmpC and New Delhi metallo-beta-lactamase-1 (NDM-1) genes among carbapenem-resistant Enterobacteriaceae (CRE) recovered prospectively from patients at multiple sites. The study included 285 CRE strains from 2782 Gram-negative Bacilli collected from multiple centres during 2007-2010, of which 87 were characterised. Standard and reference laboratory methods were used for resistance determination. Detection of blaNDM-1 , blaAmpC , blaTEM , blaSHV and blaCTX-M was done by polymerase chain reaction. High levels of antimicrobial resistance observed among study isolates. Co-carriage of ESBLs, AmpC and NDM-1 was 26.3%. Nosocomial origin among the co-carriage isolates was 64.3%, with 9.2% associated mortality.
在本研究中，我们评估了从多个地点的患者中前瞻性收集的耐碳青霉烯类肠杆菌科细菌（CRE）中，超广谱β-内酰胺酶（ESBL）、AmpC和新德里金属β-内酰胺酶-1（NDM-1）基因的共存情况。该研究纳入了2007年至2010年期间从多个中心收集的2782株革兰氏阴性杆菌中的285株CRE菌株，其中87株进行了特征分析。采用标准和参考实验室方法进行耐药性测定。通过聚合酶链反应检测blaNDM-1、blaAmpC、blaTEM、blaSHV和blaCTX-M。研究分离株中观察到高水平的抗菌药物耐药性。ESBL、AmpC和NDM-1的共携带率为26.3%。共携带分离株的医院来源为64.3%，相关死亡率为9.2%。
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