Department of Medicine, The Queen's University of Belfast, Belfast, UK.
Ir J Med Sci. 1975 Dec;144(1):375-8. doi: 10.1007/BF02939041.
This study confirms that insulin is degraded in the liver, that the immediate degradation products are its A and B chains, and that these are released to the circulation. The study also shows that the A and B chains when perfused for 31 minutes through the isolated rate livers were not degraded. The inference of the study is that the B chain is available for the production of synalbumin insulin antagonism.
本研究证实胰岛素在肝脏中降解，其直接降解产物为 A 链和 B 链，且这些链释放到血液循环中。该研究还表明，当 A 链和 B 链在离体肝脏中灌注 31 分钟时并未被降解。研究的推论是 B 链可用于合成白蛋白胰岛素拮抗物。
