瘦素与激素：能量平衡。

Leptin and Hormones: Energy Homeostasis.

机构信息

Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, ST 820, Boston, MA 02215, USA.

出版信息

Endocrinol Metab Clin North Am. 2016 Sep;45(3):633-45. doi: 10.1016/j.ecl.2016.04.012.

DOI:10.1016/j.ecl.2016.04.012

PMID:27519135

Abstract

Leptin, a 167 amino acid adipokine, plays a major role in human energy homeostasis. Its actions are mediated through binding to leptin receptor and activating JAK-STAT3 signal transduction pathway. It is expressed mainly in adipocytes, and its circulating levels reflect the body's energy stores in adipose tissue. Recombinant methionyl human leptin has been FDA approved for patients with generalized non-HIV lipodystrophy and for compassionate use in subjects with congenital leptin deficiency. The purpose of this review is to outline the role of leptin in energy homeostasis, as well as its interaction with other hormones.

摘要

瘦素是一种由 167 个氨基酸组成的脂肪细胞因子，在人体能量稳态中发挥着重要作用。它的作用是通过与瘦素受体结合并激活 JAK-STAT3 信号转导通路来介导的。它主要在脂肪细胞中表达，其循环水平反映了脂肪组织中身体的能量储存。重组甲硫氨酸人瘦素已获得 FDA 批准，可用于治疗非 HIV 相关脂肪营养不良患者，并在先天性瘦素缺乏症患者中进行同情使用。本文综述的目的是概述瘦素在能量稳态中的作用，以及它与其他激素的相互作用。