脂肪细胞激素的中枢作用。

Central actions of adipocyte hormones.

作者信息

Ahima Rexford S

机构信息

University of Pennsylvania School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, PA 19104, USA.

出版信息

Trends Endocrinol Metab. 2005 Sep;16(7):307-13. doi: 10.1016/j.tem.2005.07.010.

DOI:10.1016/j.tem.2005.07.010

PMID:16098759

Abstract

Adipose tissue secretes a variety of proteins with important roles in metabolism, reproduction, immunity and cardiovascular function. The endocrine function of adipose tissue, especially that of leptin, is linked to energy storage and thus might provide insights into obesity and other diseases associated with energy imbalance. This review highlights the current understanding of the actions of leptin in the brain, with particular emphasis on transport across the blood-brain barrier, signal transduction, neuropeptide targets and roles during fasting and obesity. Moreover, data pertaining to the potential central effects of adiponectin, cytokines and resistin on energy homeostasis, glucose and lipid metabolism are discussed.

摘要

脂肪组织分泌多种在新陈代谢、生殖、免疫和心血管功能中起重要作用的蛋白质。脂肪组织的内分泌功能，尤其是瘦素的内分泌功能，与能量储存相关，因此可能为肥胖及其他与能量失衡相关的疾病提供见解。本综述着重介绍了目前对瘦素在大脑中作用的理解，特别强调了其穿过血脑屏障的转运、信号转导、神经肽靶点以及在禁食和肥胖期间的作用。此外，还讨论了有关脂联素、细胞因子和抵抗素对能量稳态、葡萄糖和脂质代谢潜在中枢作用的数据。