儿茶酚胺和β受体阻滞剂对亚油酸去饱和活性的影响。
Effect of catecholamines and β-blockers on linoleic acid desaturation activity.
作者信息
de Gómez Dumm I N, de Alaniz M J, Brenner R R
机构信息
Instituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, calle 60 y 120, La Plata, Argentina.
出版信息
Lipids. 1978 Oct;13(10):649-52. doi: 10.1007/BF02533740.
The effect of catecholamines and adrenergic blocking agents on the oxidative desaturation of linoleic acid in rat liver microsomes was studied. Epinephrine (1 mg/kg/body weight) produced a significant decrease on the conversion of [1-(14)C]linoleic acid to γ-linolenic acid. The effect of epinephrine was blocked by single injections of the β blockers propranolol (10 mg/kg body weight) or dichloroisoproterenol 30 min before the hormone treatment. Isoproterenol (100 μg/kg body weight) produced a significant decrease on the activity of the linoleyl-CoA desaturase. The effect of the catecholamines was postulated to be mediated through β receptors by an enhancement of the intracellular levels of cyclic AMP.
研究了儿茶酚胺和肾上腺素能阻断剂对大鼠肝脏微粒体中亚油酸氧化去饱和作用的影响。肾上腺素（1毫克/千克体重）使[1-(14)C]亚油酸向γ-亚麻酸的转化显著降低。在激素处理前30分钟单次注射β受体阻滞剂普萘洛尔（10毫克/千克体重）或二氯异丙肾上腺素可阻断肾上腺素的作用。异丙肾上腺素（100微克/千克体重）使亚油酰辅酶A去饱和酶的活性显著降低。推测儿茶酚胺的作用是通过增强细胞内环磷酸腺苷（cAMP）水平，经由β受体介导的。
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