Coluccia Anna, Fagiolini Andrea, Ferretti Fabio, Pozza Andrea, Costoloni Giulia, Bolognesi Simone, Goracci Arianna
Department of Medical Sciences, Surgery and Neurosciences, Santa Maria alle Scotte University Hospital of Siena, viale Bracci 16, 53100 Siena, Italy.
Department of Molecular Medicine, University of Siena School of Medicine and Department of Mental Health, University of Siena Medical Center (AOUS), viale Bracci 16, 53100 Siena, Italy.
Asian J Psychiatr. 2016 Aug;22:41-52. doi: 10.1016/j.ajp.2016.02.001. Epub 2016 Apr 26.
In the current literature, there are no meta-analyses assessing quality of life (QOL) in patients with obsessive-compulsive disorder (OCD). Knowledge of QOL domains mainly impaired in OCD could provide specific areas for intervention. The current meta-analysis assessed differences in global, work and social, family, and emotional QOL outcomes between patients with OCD and heathy controls. Age, gender and OCD severity were examined as moderators. Case-control studies were included if patients with primary OCD were compared with controls on QOL outcomes. Electronic databases (1966-October 2014) were searched. Thirteen case-control studies were included (n=26,015). Patients with OCD had significantly lower scores on QOL relative to controls, with moderate effect sizes on global QOL and large effect size on work and social, emotional and family QOL outcomes. Studies using higher percentages of female patients and patients with less severe OCD symptoms reported significantly lower QOL outcomes for patients with OCD than controls. Studies comparing patients with OCD and patients with other psychiatric disorders were not included. Treatments should address QOL in OCD, particularly emotional QOL. Additional strategies targeting QOL should be implemented for female patients with less severe OCD symptoms.
在当前文献中，尚无针对强迫症（OCD）患者生活质量（QOL）的荟萃分析。了解强迫症中主要受损的生活质量领域可为干预提供特定领域。当前的荟萃分析评估了强迫症患者与健康对照在总体、工作与社交、家庭及情感生活质量结果方面的差异。将年龄、性别和强迫症严重程度作为调节因素进行了研究。如果将原发性强迫症患者与对照在生活质量结果方面进行比较，则纳入病例对照研究。检索了电子数据库（1966年 - 2014年10月）。纳入了13项病例对照研究（n = 26,015）。相对于对照，强迫症患者的生活质量得分显著更低，在总体生活质量方面效应量中等，在工作与社交、情感及家庭生活质量结果方面效应量较大。使用女性患者比例较高以及强迫症症状较轻患者的研究报告称，与对照相比，强迫症患者的生活质量结果显著更低。未纳入比较强迫症患者与其他精神障碍患者的研究。治疗应关注强迫症患者的生活质量，尤其是情感生活质量。对于强迫症症状较轻的女性患者，应实施针对生活质量的额外策略。
