Casan Joshua Misha Lewis, Grigoriadis George, Chan Noel, Chunilal Sanjeev
Department of Haematology, Monash Health, Clayton, Victoria, Australia.
BMJ Case Rep. 2016 Aug 12;2016:bcr2016216110. doi: 10.1136/bcr-2016-216110.
Following orthopaedic surgery, a 56-year-old woman developed heparin-induced thrombocytopenia (HIT), complicated by extensive proximal deep vein thrombosis. The patient did not respond to multiple conventional therapies; however, a prompt treatment response occurred after starting rivaroxaban at standard dosing. This case represents the first documentation of efficacy for rivaroxaban in the setting of treatment refractory HIT and strengthens the limited existing evidence for this agent in HIT.
一名56岁女性在接受骨科手术后发生肝素诱导的血小板减少症（HIT），并伴有广泛的近端深静脉血栓形成。该患者对多种传统疗法均无反应；然而，在开始使用标准剂量的利伐沙班后迅速出现治疗反应。该病例是利伐沙班在治疗难治性HIT中的疗效的首次记录，并加强了该药物在HIT中现有有限的证据。
