Liu Wei, MacDonald Margo, You Jianxin
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Curr Opin Virol. 2016 Oct;20:20-27. doi: 10.1016/j.coviro.2016.07.011. Epub 2016 Aug 10.
Merkel cell polyomavirus is the only polyomavirus discovered to date that is associated with a human cancer. MCPyV infection is highly prevalent in the general population. Nearly all healthy adults asymptomatically shed MCPyV from their skin. However, in elderly and immunosuppressed individuals, the infection can lead to a lethal form of skin cancer, Merkel cell carcinoma. In the last few years, new findings have established links between MCPyV infection, host immune response, and Merkel cell carcinoma development. This review discusses these recent discoveries on how MCPyV interacts with host cells to achieve persistent infection and, in the immunocompromised population, contributes to MCC development.
默克尔细胞多瘤病毒是迄今为止发现的唯一一种与人类癌症相关的多瘤病毒。MCPyV感染在普通人群中非常普遍。几乎所有健康成年人都无症状地从皮肤中排出MCPyV。然而,在老年人和免疫抑制个体中,这种感染可导致一种致命的皮肤癌——默克尔细胞癌。在过去几年中,新的研究结果建立了MCPyV感染、宿主免疫反应和默克尔细胞癌发生之间的联系。本综述讨论了这些关于MCPyV如何与宿主细胞相互作用以实现持续感染,以及在免疫受损人群中如何导致默克尔细胞癌发生的最新发现。