与阿尔茨海默病相比，路易体痴呆患者脑血管病变的调查。
An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease.
作者信息
Sarro Lidia, Tosakulwong Nirubol, Schwarz Christopher G, Graff-Radford Jonathan, Przybelski Scott A, Lesnick Timothy G, Zuk Samantha M, Reid Robert I, Raman Mekala R, Boeve Bradley F, Ferman Tanis J, Knopman David S, Comi Giancarlo, Filippi Massimo, Murray Melissa E, Parisi Joseph E, Dickson Dennis W, Petersen Ronald C, Jack Clifford R, Kantarci Kejal
机构信息
Department of Radiology, Mayo Clinic, Rochester, MN, USA; Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
出版信息
Alzheimers Dement. 2017 Mar;13(3):257-266. doi: 10.1016/j.jalz.2016.07.003. Epub 2016 Aug 10.
INTRODUCTION
Cerebrovascular lesions on MRI are common in Alzheimer's disease (AD) dementia, but less is known about their frequency and impact on dementia with Lewy bodies (DLB).
METHODS
White-matter hyperintensities (WMHs) and infarcts on MRI were assessed in consecutive DLB (n = 81) and AD dementia (n = 240) patients and compared to age-matched and sex-matched cognitively normal subjects (CN) from a population-based cohort.
RESULTS
DLB had higher WMH volume compared to CN, and WMH volume was higher in the occipital and posterior periventricular regions in DLB compared to AD. Higher WMH volume was associated with history of cardiovascular disease and diabetes but not with clinical disease severity in DLB. Frequency of infarcts in DLB was not different from CN and AD dementia.
DISCUSSION
In DLB, WMH volume is higher than AD and CN and appears to be primarily associated with history of vascular disease.
引言
MRI上的脑血管病变在阿尔茨海默病（AD）痴呆中很常见，但关于其在路易体痴呆（DLB）中的发生率及其对痴呆的影响知之甚少。
方法
对连续纳入的DLB患者（n = 81）和AD痴呆患者（n = 240）的MRI上的白质高信号（WMH）和梗死灶进行评估，并与来自基于人群队列的年龄和性别匹配的认知正常受试者（CN）进行比较。
结果
与CN相比，DLB的WMH体积更大，并且与AD相比，DLB在枕叶和脑室周围后部区域的WMH体积更高。较高的WMH体积与心血管疾病和糖尿病史相关，但与DLB的临床疾病严重程度无关。DLB梗死灶的发生率与CN和AD痴呆无差异。
讨论
在DLB中，WMH体积高于AD和CN，并且似乎主要与血管疾病史相关。
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