Siviy S M, Kritikos A, Atrens D M, Shepherd A
Department of Psychology, University of Sydney, NSW, Australia.
Brain Res. 1989 May 15;487(1):79-88. doi: 10.1016/0006-8993(89)90942-6.
The metabolic effects of norepinephrine (NE), when infused into the paraventricular nucleus of the hypothalamus (PVN), were examined using indirect calorimetry. In two separate experiments, it was found that NE infused into the PVN reduced energy expenditure in freely moving rats. While NE also reduced motor activity, these reductions were not statistically significant. Reductions in voluntary motor activity were not necessary for a reduction in energy expenditure, as NE still reduced energy expenditure in rats that were lightly sedated. Clonidine, but not L-phenylephrine, mimicked the hypometabolic effect of NE, suggesting an action at alpha 2 receptors. Infusions of NE were also found to increase blood glucose shortly after infusion, although the specificity of this effect is questionable. Taken together, these data suggest that activation of noradrenergic neurons within the PVN results in a metabolic shift towards energy conservation.
利用间接测热法研究了将去甲肾上腺素（NE）注入下丘脑室旁核（PVN）后的代谢效应。在两个独立实验中发现，向PVN注入NE可降低自由活动大鼠的能量消耗。虽然NE也会降低运动活性，但这些降低在统计学上并不显著。自愿运动活性的降低对于能量消耗的减少并非必要，因为NE仍可降低轻度镇静大鼠的能量消耗。可乐定而非L - 去氧肾上腺素模拟了NE的低代谢效应，提示其作用于α2受体。还发现注入NE后不久血糖会升高，尽管这种效应的特异性存在疑问。综上所述，这些数据表明PVN内去甲肾上腺素能神经元的激活导致代谢向能量保存方向转变。
