Ho Caleb, Kluk Michael J
Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Department of Pathology, Weill Cornell Medical College, 525 East 68th Street, Mailbox #79, F-540, New York, NY 10065, USA.
Surg Pathol Clin. 2016 Sep;9(3):489-521. doi: 10.1016/j.path.2016.04.011.
Lymphoid neoplasms show great diversity in morphology, immunophenotypic profile, and postulated cells of origin, which also reflects the variety of genetic alterations within this group of tumors. This review discusses many of the currently known genetic alterations in selected mature B-cell and T-cell lymphoid neoplasms, and their significance as diagnostic, prognostic, and therapeutic markers. Given the rapidly increasing number of genetic alterations that have been described in this group of tumors, and that the clinical significance of many is still being studied, this is not an entirely exhaustive review of all of the genetic alterations that have been reported.
淋巴瘤在形态学、免疫表型特征及假定的起源细胞方面表现出极大的多样性，这也反映了该组肿瘤内基因改变的多样性。本综述讨论了某些成熟B细胞和T细胞淋巴瘤中目前已知的许多基因改变，以及它们作为诊断、预后和治疗标志物的意义。鉴于该组肿瘤中已描述的基因改变数量迅速增加，且许多改变的临床意义仍在研究中，因此这并非对所有已报道基因改变的详尽综述。
