反复种植失败患者改良自然周期冻融胚胎移植：一项观察性研究。
Modified natural cycle frozen-thawed embryo transfer in patients with repeated implantation failure: An observational study.
作者信息
Arefi Soheila, Hoseini Ahmad, Farifteh Fattaneh, Zeraati Hojjat
机构信息
Avicenna Research Institute, Shahid Beheshti University, Tehran, Iran.; GIVAR (Genetic & In Vitro Assisted Reproduction) Center, Erfan hospital, Tehran, Iran.
GIVAR (Genetic & In Vitro Assisted Reproduction) Center, Erfan hospital, Tehran, Iran.; Cellular and Molecular Biology Research Center, Shahid Beheshti University, Tehran, Iran.
出版信息
Int J Reprod Biomed. 2016 Jul;14(7):465-70.
BACKGROUND
Natural endometrium in Frozen-thawed Embryo Transfer (FET) may have some benefits upon implantation in patients with Repeated Implantation Failure (RIF). It might be due to possible differences between natural and stimulated endometrial growth factors and cytokins secretions.
OBJECTIVE
The objective of this study was to compare the pregnancy rate of FET on modified natural cycle versus hormone replacement therapy (HRT) cycle endometrium in patients with RIF.
MATERIALS AND METHODS
In this observational study the pregnancy rate of patients with RIF undergoing day 3 FET in natural cycle endometrium (group 1, n=56), were compared with another group of patients with RIF in whom frozen-thawed day 3 embryos were transferred on HRT cycle (group 2, n=52).
RESULTS
The pregnancy rate in group 1 was 41.07%, compared with the pregnancy rate of group 2; 36.5% (p=0.63). The abortion rate was not significantly different among the groups.
CONCLUSION
It can be concluded that FET in a modified natural cycle is comparable with HRT cycle in patients with RIF.
背景
在冻融胚胎移植（FET）中，自然子宫内膜对于反复种植失败（RIF）患者的着床可能具有一些益处。这可能是由于自然与刺激子宫内膜生长因子和细胞因子分泌之间存在可能的差异。
目的
本研究的目的是比较RIF患者在改良自然周期与激素替代疗法（HRT）周期子宫内膜上进行FET的妊娠率。
材料与方法
在这项观察性研究中，将在自然周期子宫内膜上进行第3天FET的RIF患者（第1组，n = 56）的妊娠率与另一组在HRT周期上移植冻融第3天胚胎的RIF患者（第2组，n = 52）进行比较。
结果
第1组的妊娠率为41.07%，与第2组的妊娠率36.5%相比（p = 0.63）。各组间流产率无显著差异。
结论
可以得出结论，改良自然周期的FET与RIF患者的HRT周期相当。
Zotero 插件