Akhtar Nida, Varma Anurag, Pathak Kamla
Department of Pharmaceutics, Pharmacy College Saifai, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, 206130, India.
Curr Clin Pharmacol. 2016;11(3):168-190. doi: 10.2174/1574884711666160813231352.
Drug delivery across the deeper layers of skin to make it systemically available is a considerable challenge in the development of a carrier. Numerous efforts have been put forward to find ways to overcome the formidable barrier of stratum corneum. Various lipid based vesicles viz liposomes, transfersomes, and invasomes have gained prominent deliberations across the globe. More recently, ethosomes have been investigated for their potential for transdermal delivery of several drugs.
In the present review an attempt has been made to illustrate preclinical and clinical studies depicting enhanced safety and efficacy of drugs delivered via ethosomes. Further, patents on transdermal delivery have been highlighted specifying the effectiveness of ethosomes in the transport of therapeutic actives.
Through the search engine "Scopus" literature on therapeutic categories such as antimicrobials, anti-inflammatory, and drugs acting on CNS has been collected.
Preclinical and clinical studies that have been carried out by various researchers affirm the potentiality of ethosomes for delivering wide variety of drugs belonging to different therapeutic categories. In vitro and in vivo permeability analyses delineated the enhancement of permeability. Consequently, enhanced transdermal flux was reported and in vivo confocal laser scanning microscopy depicted the quantity as well as depth of penetrability via ethosomes.
From various research reports, it can be concluded that ethosomes are the competent and efficient vesicles to provide better drug transport via transdermal route.
药物透过皮肤深层以实现全身可用性是载体开发中的一项重大挑战。人们已经做出了许多努力来寻找克服角质层这一巨大屏障的方法。各种基于脂质的囊泡，如脂质体、传递体和侵入体，在全球范围内受到了广泛关注。最近，乙醇脂质体因其在多种药物透皮递送方面的潜力而受到研究。
在本综述中，试图阐述临床前和临床研究，这些研究描述了通过乙醇脂质体递送药物的更高安全性和有效性。此外，还强调了透皮递送方面的专利，明确了乙醇脂质体在治疗活性物质运输中的有效性。
通过搜索引擎“Scopus”收集了关于抗菌、抗炎和作用于中枢神经系统等治疗类别的文献。
不同研究人员进行的临床前和临床研究证实了乙醇脂质体在递送属于不同治疗类别的多种药物方面的潜力。体外和体内渗透性分析表明渗透性增强。因此，报告了透皮通量的增加，并且体内共聚焦激光扫描显微镜显示了通过乙醇脂质体的渗透量和深度。
从各种研究报告可以得出结论，乙醇脂质体是通过透皮途径提供更好药物运输的有效且高效的囊泡。
