Kautzner Josef, Peichl Petr
Head;
Consultant Electrophysiologist, Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Arrhythm Electrophysiol Rev. 2013 Nov;2(2):135-40. doi: 10.15420/aer.2013.2.2.135. Epub 2013 Nov 29.
Recently, catheter ablation (CA) has become a therapeutic option to target focal triggers of polymorphic ventricular tachycardia and ventricular fibrillation (VF) in the setting of electrical storm (ES). This strategy was first described in subjects without organic heart disease (i.e. idiopathic VF) and subsequently in other conditions, especially in patients with ischaemic heart disease. In the majority of cases, the triggering focus originates in the ventricular Purkinje system. In patients with Brugada syndrome, besides ablation of focal trigger in the right ventricular outflow tract, modification of a substrate in this region has been described to prevent recurrences of VF. In conclusion, CA appears to be a reasonable strategy for intractable cases of ES due to focally triggered polymorphic ventricular tachycardia and VF. Therefore, early transport of the patient into the experience centre for CA should be considered since the procedure could be in some cases life-saving. Therefore, the awareness of this entity and link to the nearest expert centre are important.
最近,导管消融术(CA)已成为针对电风暴(ES)情况下多形性室性心动过速和心室颤动(VF)的局灶性触发因素的一种治疗选择。这一策略最初是在无器质性心脏病的患者(即特发性VF)中描述的,随后也应用于其他情况,尤其是缺血性心脏病患者。在大多数情况下,触发灶起源于心室浦肯野系统。在Brugada综合征患者中,除了消融右心室流出道的局灶性触发因素外,还描述了对该区域基质的改良以预防VF复发。总之,对于由局灶性触发的多形性室性心动过速和VF导致的难治性ES病例,CA似乎是一种合理的策略。因此,应考虑尽早将患者转运至CA经验中心,因为该手术在某些情况下可能挽救生命。所以,认识到这一情况并与最近的专家中心建立联系很重要。