治疗即预防：HIV预防试验网络052试验中伴侣感染的特征分析
Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial.
作者信息
Eshleman Susan H, Hudelson Sarah E, Redd Andrew D, Swanstrom Ronald, Ou San-San, Zhang Xinyi Cindy, Ping Li-Hua, Piwowar-Manning Estelle, Porcella Stephen F, Sievers Matthew F, Martens Craig A, Bruno Daniel, Dukhovlinova Elena, McCauley Marybeth, Gamble Theresa, Fogel Jessica M, Sabin Devin, Quinn Thomas C, Gunde Laurence, Maliwichi Madalitso, Nhando Nehemiah, Akelo Victor, Moyo Sikhulile, Panchia Ravindre, Kumarasamy Nagalingeswaran, Chotirosniramit Nuntisa, Melo Marineide Gonçalves de, Pilotto Jose, Grinsztejn Beatriz, Mayer Kenneth, Chen Ying Q, Hughes James P, Cohen Myron S
机构信息
*Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; †Laboratory of Immunoregulation, NIAID, NIH, Baltimore, MD; ‡Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC; §Vaccine and Infectious Disease Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA; ‖Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; ¶Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, DIR, NIAID, NIH, Hamilton, MT; #Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; **Science Facilitation Department, FHI360, Washington, DC; ††Science Facilitation Department, FHI360, Durham, NC; ‡‡College of Medicine-Johns Hopkins Project, Blantyre, Malawi; §§UNC Project, Lilongwe, Malawi; ‖‖Department of Medicine, University of Zimbabwe, Harare, Zimbabwe; ¶¶HIV Research Branch, Center for Global Health, Kenya Medical Research Institute (KEMRI)-Centers for Disease Control (CDC), Kisumu, Kenya; ##BHHRL & Clinical Trials Unit, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; ***Soweto HPTN CRS, Chris Hani Baragwanath Hospital, Soweto, South Africa; †††YRGCARE Medical Centre, Chennai, India; ‡‡‡Center for AIDS and STDs, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; §§§Hospital Nossa Senhora da Conceição, Serviço de Infectologia, Porto Alegre, Brazil; ‖‖‖Hospital Geral de Nova Iguaçu and Laboratorio de AIDS e Imunologia Molecular (IOC/Fiocruz), Rio de Janeiro, Brazil; ¶¶¶Instituto Nacional de Infectologia Evandro Chagas-INI-Fiocruz, Rio de Janeiro, Brazil; ###Fenway Health and Infectious Disease Division, The Fenway Institute, Boston, MA; ****Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA; ††††Vaccine and Infectious Disease Division and Public Health Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA; ‡‡‡‡Department of Biostatistics, University of Washington, Seattle, WA; and §§§§Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
出版信息
J Acquir Immune Defic Syndr. 2017 Jan 1;74(1):112-116. doi: 10.1097/QAI.0000000000001158.
HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.
艾滋病预防试验网络052研究表明，抗逆转录病毒疗法（ART）可预防血清学不一致伴侣间的HIV传播。对来自索引伴侣对的HIV进行分析，以确定伴侣感染的基因连锁状态。46例感染被归类为连锁感染，这表明索引病例可能是其伴侣感染的来源。病毒抑制不足和索引病例较高的病毒载量与连锁感染有关。8例连锁感染是在索引病例开始接受ART治疗后被诊断出来的：4例在开始ART治疗时附近，4例在ART治疗失败后。当索引参与者在ART治疗中得到稳定抑制时，未观察到连锁感染。
Zotero 插件