He Qian, Ni Yongkang, Li Yuefei, Hu Xiaoyuan, Hu Xiaomin, Ni Zhen, Zeng Changyu, Aikebaier Aizimaiti, Xu Bixin, Ni Mingjian
School of public health, Xinjiang Medical University, Urumqi, 830017, China.
Xinjiang Uighur Autonomous Region Center for Disease Control and Prevention, Urumqi, 830002, China.
BMC Public Health. 2025 Jan 11;25(1):128. doi: 10.1186/s12889-025-21278-6.
New indicators of potential human immunodeficiency virus (HIV) transmission are being actively explored. We aim to categorical testing of the viral load (VL) of persons living with HIV (PLWH) in order to explore new indicators to measure the intensity of the epidemic and the effectiveness of the response in the community.
A dynamic cohort study was conducted in Yining to monitor the VL of all persons living with HIV from 2017 to 2019. Different population VL (PVL) surrogate indicators were measured and the strength of the associations of different PVL surrogates with HIV incidence, antiretroviral therapy (ART) coverage, virus unsuppression, and viremia prevalence was assessed. PVL surrogate indicators were used to describe the current status of HIV transmission in different populations and communities.
All PVL indicators decreased from 2017 to 2019 (P < 0.05). Arithmetic mean community viral load (CVL) (r = 1.000, P = 0.006) and geometric mean CVL (r = 1.000, P = 0.001) were positively associated with HIV incidence, ART coverage and viral unsuppression (P < 0.05). CVL was higher in the male, ≤ 25 years of age, primary school or below, other household registration, other medical insurance types, other source of sample, nonmarital and noncommercial heterosexual contact, and nonmarital and commercial heterosexual contact subgroups. Community-based cross-sectional analyses showed that CVL in community 10 was positively correlated with viral unsuppression rate and viremia prevalence but negatively correlated with ART coverage rate, suggesting that the community was a hotspot for HIV epidemics.
CVL can be used as an indicator for assessing HIV transmission and identifying high-risk populations and hotspot communities.
目前正在积极探索潜在的人类免疫缺陷病毒（HIV）传播新指标。我们旨在对HIV感染者（PLWH）的病毒载量（VL）进行分类检测，以探索新指标来衡量疫情强度及社区应对措施的有效性。
在伊宁开展了一项动态队列研究，以监测2017年至2019年所有HIV感染者的VL。测量了不同的人群病毒载量（PVL）替代指标，并评估了不同PVL替代指标与HIV发病率、抗逆转录病毒治疗（ART）覆盖率、病毒未被抑制情况及病毒血症患病率之间关联的强度。PVL替代指标用于描述不同人群和社区中HIV传播的现状。
2017年至2019年期间，所有PVL指标均下降（P < 0.05）。算术平均社区病毒载量（CVL）（r = 1.000，P = 0.006）和几何平均CVL（r = 1.000，P = 0.001）与HIV发病率、ART覆盖率及病毒未被抑制情况呈正相关（P < 0.05）。在男性、年龄≤25岁、小学及以下学历、其他户籍、其他医疗保险类型、其他样本来源、非婚及非商业异性接触以及非婚及商业异性接触亚组中，CVL较高。基于社区的横断面分析表明，社区10中的CVL与病毒未被抑制率和病毒血症患病率呈正相关，但与ART覆盖率呈负相关，这表明该社区是HIV流行的热点地区。
CVL可作为评估HIV传播以及识别高危人群和热点社区的指标。
