1960年至2010年按十年划分的原发性银屑病出版物类型趋势。
Trends in Type of Original Psoriasis Publications by Decade, 1960 to 2010.
作者信息
Sako Eric, Famenini Shannon, Wu Jashin J
机构信息
Dermatology Resident at the University of California, Los Angeles.
Resident in the Department of Internal Medicine at University of California, Irvine.
出版信息
Perm J. 2016 Fall;20(4):15-060. doi: 10.7812/TPP/15-060. Epub 2016 Aug 15.
CONTEXT
Research investigating psoriasis has spanned decades, and as our understanding of the disease has evolved, the focus of publications has changed.
OBJECTIVE
We sought to characterize the trends in original psoriasis-related research from 1960 to 2010 chronologically by decade.
METHODS
A literature review was performed using the keyword psoriasis in the MEDLINE database. All original psoriasis-related articles published at the beginning of each decade were searched and categorized by study type and topic.
MAIN OUTCOME MEASURE
Number of articles per topic.
RESULTS
A total of 869 original psoriasis-related articles were found. The number of publications increased 18 fold over 5 decades. The immunology and pathogenesis of psoriasis was the most frequently researched topic (36%), and retrospective studies were the most common study type (37%). Recent highly published topics included biologic therapy, genetics, and psoriasis-associated cardiovascular disease.
CONCLUSION
Original psoriasis-related publications have grown substantially since 1960. Basic science research into the immunology and pathogenesis has been and continues to be the mainstay of psoriasis research. Recent research trends suggest the focus has expanded to topics such as psoriasis-associated cardiovascular disease, genetics, and biologic therapy.
背景
对银屑病的研究已历经数十年，随着我们对该疾病认识的不断发展，出版物的重点也发生了变化。
目的
我们试图按时间顺序按十年为单位描述1960年至2010年与银屑病相关的原创性研究的趋势。
方法
使用MEDLINE数据库中的关键词“银屑病”进行文献综述。搜索了每个十年初发表的所有与银屑病相关的原创文章，并按研究类型和主题进行分类。
主要观察指标
每个主题的文章数量。
结果
共发现869篇与银屑病相关的原创文章。在50年中，出版物数量增加了18倍。银屑病的免疫学和发病机制是研究最频繁的主题（36%），回顾性研究是最常见的研究类型（37%）。近期发表量较高的主题包括生物治疗、遗传学和银屑病相关的心血管疾病。
结论
自1960年以来，与银屑病相关的原创性出版物大幅增加。对免疫学和发病机制的基础科学研究一直是且仍然是银屑病研究的支柱。近期的研究趋势表明，重点已扩展到银屑病相关的心血管疾病、遗传学和生物治疗等主题。
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