Sabat Robert, Sterry Wolfram, Philipp Sandra, Wolk Kerstin
Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, D-10117 Berlin, Germany.
Clin Dermatol. 2007 Nov-Dec;25(6):504-9. doi: 10.1016/j.clindermatol.2007.08.002.
Psoriasis is a common chronic skin disease. Its pathogenesis has intensively been investigated in the last 3 decades. In the 1970s, the observed increased proliferation of keratinocytes and their altered differentiation were considered to be the most important signs and causes of psoriatic skin lesions. Since the early 1980s, T cells slid into the focus of psoriasis research. It was then postulated that a subpopulation of T cells, so-called T1 cells, and their prominent cytokine interferon-gamma, had a dominant role in the pathogenesis of psoriasis. In the last decade, new data regarding macrophages and dendritic cells and the high therapeutic success of anti-tumor necrosis factor alpha biologics led to the assumption that antigen-presenting cells are important not only in the induction of psoriasis but also in its maintenance. The knowledge gained over the past 3 decades let us postulate that psoriasis is an immunologically induced, overshot, regeneration-like reaction of the skin in which various cells play a dominant role at different stages. This hypothesis is also supported by the very recent discoveries about interleukin (IL)-22, IL-20, and IL-23.
银屑病是一种常见的慢性皮肤病。在过去30年里，对其发病机制进行了深入研究。在20世纪70年代，观察到的角质形成细胞增殖增加及其分化改变被认为是银屑病皮肤病变的最重要体征和病因。自20世纪80年代初以来，T细胞成为银屑病研究的焦点。当时推测，一个T细胞亚群，即所谓的T1细胞，及其突出的细胞因子γ干扰素，在银屑病发病机制中起主导作用。在过去十年中，关于巨噬细胞和树突状细胞的新数据以及抗肿瘤坏死因子α生物制剂的高治疗成功率导致人们认为抗原呈递细胞不仅在银屑病的诱发中起重要作用，而且在其维持中也起重要作用。过去30年获得的知识使我们推测，银屑病是一种免疫诱导的、过度的、类似再生的皮肤反应，其中各种细胞在不同阶段起主导作用。白细胞介素（IL）-22、IL-20和IL-23的最新发现也支持了这一假说。
