光学相干断层扫描中使用微泡的微血管对比增强。
Microvascular contrast enhancement in optical coherence tomography using microbubbles.
机构信息
Ryerson University, Department of Physics, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada.
University of Toronto, Department of Medical Biophysics, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Room 15-701, Toronto, Ontario M5G 1L7, Canada.
出版信息
J Biomed Opt. 2016 Jul 1;21(7):76014. doi: 10.1117/1.JBO.21.7.076014.
Gas microbubbles (MBs) are investigated as intravascular optical coherence tomography (OCT) contrast agents. Agar + intralipid scattering tissue phantoms with two embedded microtubes were fabricated to model vascular blood flow. One was filled with human blood, and the other with a mixture of human blood + MB. Swept-source structural and speckle variance (sv) OCT images, as well as speckle decorrelation times, were evaluated under both no-flow and varying flow conditions. Faster decorrelation times and higher structural and svOCT image contrasts were detected in the presence of MB in all experiments. The effects were largest in the svOCT imaging mode, and uniformly diminished with increasing flow velocity. These findings suggest the feasibility of utilizing MB for tissue hemodynamic investigations and for microvasculature contrast enhancement in OCT angiography.
气体微泡（MBs）被研究作为血管内光相干断层扫描（OCT）造影剂。琼脂+脂内散射组织体模，内置两个微管，用于模拟血管血流。一个充满了人体血液，另一个充满了人体血液+MB 混合物。在无流动和不同流动条件下，评估了扫频源结构和散斑方差（sv）OCT 图像以及散斑去相关时间。在所有实验中，存在 MB 时，检测到更快的去相关时间和更高的结构和 svOCT 图像对比度。在 svOCT 成像模式下，这些效果最大，并且随着流速的增加而均匀减小。这些发现表明，利用 MB 进行组织血液动力学研究以及在 OCT 血管造影中增强微血管对比度是可行的。
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