Cancer Center, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, China.
Centre for Cognitive and Brain Sciences, University of Macau, Taipa, Macau SAR 999078, China.
ACS Nano. 2024 Mar 26;18(12):9187-9198. doi: 10.1021/acsnano.4c01204. Epub 2024 Mar 11.
Optical coherence tomography (OCT) imaging mainly uses backscattered light to visualize the structural and functional information on biological tissues. In particular, OCT angiography can not only map the capillary networks but also capture the blood flow in the tissue microenvironment, making it a good candidate for neuroimaging and tumor imaging and in real time. To further improve the detection accuracy of cancer or brain disorders, it is essential to develop a natural and nontoxic contrast agent for enhanced OCT imaging in the second near-infrared (NIR-II) window. In this study, a superior biocompatible and highly scattering NIR-II fat nanoemulsion was constructed to improve OCT imaging contrast and depth for monitoring the vascular network changes of the cerebral cortex or tumor. experimental results demonstrated that a natural fat nanoemulsion can serve as an excellent probe for enhanced OCT neuroimaging and tumor imaging.
光学相干断层扫描（OCT）成像主要利用背向散射光来可视化生物组织的结构和功能信息。特别是，OCT 血管造影不仅可以绘制毛细血管网络，还可以捕获组织微环境中的血流，使其成为神经成像和肿瘤成像的理想选择，并且可以实时进行。为了进一步提高癌症或脑部疾病的检测准确性，有必要开发一种用于增强近红外二区（NIR-II）窗口中的 OCT 成像的自然无毒的对比剂。在这项研究中，构建了一种优越的生物相容性和高散射的 NIR-II 脂肪纳米乳剂，以提高 OCT 成像对比度和深度，用于监测大脑皮层或肿瘤的血管网络变化。实验结果表明，天然脂肪纳米乳剂可用作增强 OCT 神经成像和肿瘤成像的优异探针。
