A case of glandular intraepithelial neoplasia involving the cervix and vagina.

A case of high grade glandular intraepithelial neoplasia (GIN) of the vagina is described. This lesion developed 5 years after hysterectomy, which had been carried out because of histologically incomplete excision of cervical adenocarcinoma in situ, despite two conizations. The vaginal lesion was treated by local excision and subsequent radiotherapy to the vagina. The literature contains reference to only one case of vaginal adenocarcinoma in situ, which was successfully treated by local excision. The possible histogenesis of this lesion is discussed and recommendations made for follow-up of patients who have received treatment for high grade cervical or vaginal GIN.