Kalogirou D, Antoniou G, Karakitsos P, Botsis D, Papadimitriou A, Giannikos L
2nd Department of Obstetrics and Gynecology, Areteion Hospital, University of Athens, Greece.
Eur J Gynaecol Oncol. 1997;18(3):188-91.
To determine the number of patients with carcinoma in situ of the cervix treated by hysterectomy who proceeded to develop vaginal intraepithelial neoplasia (VAIN) and define whether the subsequent development of VAIN justifies intensive cytology and colposcopy follow-up.
Nine hundred and ninety-three women who were subjected to hysterectomy with CIN, (793 patients had completed 10 years of cytology and colposcopy follow-up) were identified.
Forty-one patients with VAIN presented with CIN 3 after hysterectomy. The upper one half of the vagina was the area more affected. The middle age group developed VAIN in the shortest time. Atypical Cells (ASCUS) were found in 42% of these patients. Colposcopy revealed VAIN involving the vault angles of the suture line in 54% of the cases. In 51% of the cases the grade of vaginal abnormality was the same as that of the original lesion in the cervix.
With such data we would propose screening over a 5-year period. Follow-up should also include colposcopic review during every examination.
确定接受子宫切除术治疗的宫颈原位癌患者中发生阴道上皮内瘤变（VAIN）的患者数量，并确定VAIN的后续发生是否需要进行密集的细胞学和阴道镜检查随访。
确定了993例因宫颈上皮内瘤变（CIN）接受子宫切除术的女性，其中793例患者已完成10年的细胞学和阴道镜检查随访。
41例VAIN患者在子宫切除术后出现CIN 3。阴道上半部分是受影响更严重的区域。中年组在最短时间内发生VAIN。这些患者中有42%发现非典型细胞（ASCUS）。阴道镜检查显示，54%的病例中VAIN累及缝合线的穹窿角。51%的病例中阴道异常分级与宫颈原发病变相同。
基于这些数据，我们建议进行为期5年的筛查。每次检查的随访还应包括阴道镜复查。
