Aillard Paul, Dova Davide, Magné Valentin, Retailleau Pascal, Cauteruccio Silvia, Licandro Emanuela, Voituriez Arnaud, Marinetti Angela
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, Université Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France.
Chem Commun (Camb). 2016 Sep 21;52(73):10984-7. doi: 10.1039/c6cc04765c. Epub 2016 Aug 18.
Substituted phosphathiahelicenes have been prepared via a straightforward two-step procedure involving the regioselective bromination of a preformed helical scaffold, followed by palladium catalyzed coupling reactions. The new helicenes have been used as ligands in gold(i)-catalyzed [4+2] cyclizations of 1,6-enynes. The resulting dihydro-cyclopenta[b]naphthalene derivative was obtained in excellent yields and with up to 91% ee.
通过一个简单的两步程序制备了取代的磷杂硫杂并苯，该程序包括对预先形成的螺旋支架进行区域选择性溴化，然后进行钯催化的偶联反应。这些新型硫杂并苯已被用作配体，用于金（I）催化的1,6-烯炔的[4+2]环化反应。所得的二氢环戊并[b]萘衍生物的产率极高，对映体过量率高达91%。
