国家结直肠癌筛查计划中的间期癌。
Interval cancers in a national colorectal cancer screening programme.
机构信息
Centre for Research into Cancer Prevention and Screening (CRiPS), University of Dundee, Dundee, UK.
Information Services, National Services Scotland, Edinburgh, UK.
出版信息
United European Gastroenterol J. 2016 Aug;4(4):587-94. doi: 10.1177/2050640615624294. Epub 2016 Jan 6.
BACKGROUND
Little is known about interval cancers (ICs) in colorectal cancer (CRC) screening.
OBJECTIVE
The purpose of this study was to identify IC characteristics and compare these with screen-detected cancers (SCs) and cancers in non-participants (NPCs) over the same time period.
DESIGN
This was an observational study done in the first round of the Scottish Bowel Screening Programme. All individuals (772,790), aged 50-74 years, invited to participate between 1 January 2007 and 31 May 2009 were studied by linking their screening records with confirmed CRC records in the Scottish Cancer Registry (SCR). Characteristics of SC, IC and NPC were determined.
RESULTS
There were 555 SCs, 502 ICs and 922 NPCs. SCs were at an earlier stage than ICs and NPCs (33.9% Dukes' A as against 18.7% in IC and 11.3% in NPC), screening preferentially detected cancers in males (64.7% as against 52.8% in IC and 59.7% in NPC): this was independent of a different cancer site distribution in males and females. SC in the colon were less advanced than IC, but not in the rectum.
CONCLUSION
ICs account for 47.5% of the CRCs in the screened population, indicating approximately 50% screening test sensitivity: guaiac faecal occult blood testing (gFOBT) sensitivity is less for women than for men and gFOBT screening may not be effective for rectal cancer.
背景
结直肠癌（CRC）筛查中对间期癌（IC）知之甚少。
目的
本研究旨在确定 IC 的特征，并将其与同期筛查检出的癌症（SCs）和非参与者中的癌症（NPCs）进行比较。
设计
这是在苏格兰结直肠筛查计划第一轮中进行的一项观察性研究。所有年龄在 50-74 岁之间、于 2007 年 1 月 1 日至 2009 年 5 月 31 日受邀参加筛查的个体（772790 人），通过将其筛查记录与苏格兰癌症登记处（SCR）中确认的 CRC 记录相链接进行研究。确定了 SC、IC 和 NPC 的特征。
结果
共发现 555 例 SC、502 例 IC 和 922 例 NPC。SCs 比 ICs 和 NPCs 更早（33.9%为 Dukes' A 期，而 IC 为 18.7%，NPC 为 11.3%），筛查优先发现男性癌症（64.7%，IC 为 52.8%，NPC 为 59.7%）：这与男性和女性不同的癌症部位分布无关。结肠 SC 比 IC 不那么晚期，但直肠不是。
结论
IC 占筛查人群中 CRC 的 47.5%，表明筛查试验的敏感性约为 50%：愈创木脂粪便潜血试验（gFOBT）对女性的敏感性低于男性，gFOBT 筛查可能对直肠癌无效。
Zotero 插件