白细胞介素-33在肺损伤中的信号传导
IL-33 Signaling in Lung Injury.
作者信息
Chang Jing, Xia Yue-Feng, Zhang Ma-Zhong, Zhang Li-Ming
机构信息
Department of Anesthesiology, Shanghai Children's Medical Center, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai, P.R. China.
Department of Anesthesiology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, U.S.A.
出版信息
Transl Perioper Pain Med. 2016;1(2):24-32.
Abstract
Interleukin (IL)-33, a member of the IL-1 cytokine super-family, acts as both a traditional cytokine and an intracellular nuclear factor. It is generally released from damaged immune cells and signals through its receptor ST2 in an autocrine and paracrine fashion, plays important roles in type-2 innate immunity, and functions as an "alarmin" or a danger signal for cellular damage or cellular stress. Here, we review recent advances of the role of IL-33 in lung injury and explore its potential significance as an attractive therapeutic target.
摘要
白细胞介素（IL）-33是IL-1细胞因子超家族的成员，兼具传统细胞因子和细胞内核因子的功能。它通常从受损的免疫细胞中释放出来，通过其受体ST2以自分泌和旁分泌方式发出信号，在2型固有免疫中发挥重要作用，并作为细胞损伤或细胞应激的“警报素”或危险信号发挥作用。在此，我们综述了IL-33在肺损伤中作用的最新进展，并探讨了其作为有吸引力的治疗靶点的潜在意义。
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