Nghiem-Rao T Hang
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Nutr Clin Pract. 2016 Oct;31(5):619-28. doi: 10.1177/0884533616663487. Epub 2016 Aug 18.
Infants and children who depend on parenteral nutrition are among the most vulnerable to developing potentially devastating intestinal failure-associated liver disease. While the pathogenesis of intestinal failure-associated liver disease remains unclear, evidence for the contribution of fat emulsions to cholestasis and liver injury has rapidly increased in recent years. Data demonstrating the interaction among phytosterols, fatty acids, and antioxidants in cellular pathways that mediate bile flow and hepatic injury have led to the development of newer alternative fat emulsions. This article reviews recent studies that have provided insight into the potential hepatotoxicities of fat emulsions.
依赖肠外营养的婴幼儿是最易患可能具有毁灭性的肠衰竭相关肝病的群体之一。虽然肠衰竭相关肝病的发病机制尚不清楚，但近年来，关于脂肪乳剂导致胆汁淤积和肝损伤的证据迅速增多。有数据表明，植物甾醇、脂肪酸和抗氧化剂在介导胆汁流动和肝损伤的细胞途径中相互作用，这促使了新型替代脂肪乳剂的研发。本文综述了近期对脂肪乳剂潜在肝毒性有深入见解的研究。
