脑中枢神经细胞瘤的临床特征及预后因素

Clinical characteristics and prognostic factors of brain central neurocytoma.

作者信息

Song Yaqi, Kang Xinle, Cao Gang, Li Yongqiang, Zhou Xilei, Tong Yusuo, Wang Wanwei

机构信息

Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.

Department of Ophthalmology, Huai'an Second People's Hospital, Xuzhou Medical College, Huai'an, China.

出版信息

Oncotarget. 2016 Nov 15;7(46):76291-76297. doi: 10.18632/oncotarget.11228.

DOI:10.18632/oncotarget.11228

PMID:27542237

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5342814/

Abstract

BACKGROUND & AIMS: This study is designed for the clinical characteristics and prognostic factors of central neurocytoma (CN).

METHODS

CN patients from 2004 to 2012 were enrolled from the Surveillance Epidemiology and End Results (SEER) data. Clinical characteristics including age, sex, race, tumor size, tumor number, surgery, and radiation therapy were summarized. Univariate and multivariate analysis were performed to explore the prognostic factors of CN.

RESULTS

CN tended to be borderline malignant and single lesion. Compared with other brain tumor (NCN), Patients with CN (CNs) were more likely to be female, young, and non-white race. Surgery was the primary treatment of CN. Univariate and Multivariate analysis indicated tumor number and surgery were both independent prognostic factors of CN (P < 0.05). Unifocal CNs had a lower mortality risk than multifocal ones (HR 0.167, 95% CI 0.052-0.537), surgery significantly reduced the death risk of CNs (HR 0.284, 95% CI 0.088-0.921).

CONCLUSIONS

CN tend to be borderline malignant, single lesion, operated on. Most CNs are female and younger. single lesion and surgery are the independent positive prognostic factors of CN.

摘要

背景与目的

本研究旨在探讨中枢神经细胞瘤（CN）的临床特征及预后因素。

方法

从监测、流行病学和最终结果（SEER）数据库中纳入2004年至2012年的CN患者。总结患者的临床特征，包括年龄、性别、种族、肿瘤大小、肿瘤数量、手术及放疗情况。采用单因素和多因素分析来探究CN的预后因素。

结果

CN多为交界性恶性且为单发病灶。与其他脑肿瘤（NCN）相比，CN患者更可能为女性、年轻且为非白种人。手术是CN的主要治疗方式。单因素和多因素分析表明肿瘤数量和手术均为CN的独立预后因素（P < 0.05）。单发性CN的死亡风险低于多发性CN（HR 0.167，95%CI 0.052 - 0.537），手术显著降低了CN患者的死亡风险（HR 0.284，95%CI 0.088 - 0.921）。