Azzu Vian
Hinchingbrooke Hospital, Hinchingbrooke Park, Huntingdon, PE29 6NT, UK.
Department of Medicine, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK.
BMC Gastroenterol. 2016 Aug 19;16(1):96. doi: 10.1186/s12876-016-0510-8.
Gastropericardial fistula is a rare life-threatening condition, being reported only 65 times in modern literature.
A 67 year-old man who presented with weight loss, chest pain and epigastric pain was found to have pericardial effusion and pneumopericardium on computed imaging. Endoscopy and histology confirmed a gastric adenocarcinoma within a hiatus hernia, which had fistulated to the pericardium. His condition was complicated by pulmonary emboli and lobar infarction, all contributing to rapid deterioration and death.
Review of all previously published cases reveals that factors which predict poorer prognosis are older age, cancer etiology and conservative management. Conversely, protective factors include younger age at presentation, previous gastroesophageal surgery or ulcers as an etiology, and aggressive procedural and surgical management. Although the diagnosis is viewed as largely fatal by many clinicians, operative management has contributed to a statistically significant reduction in mortality from 69 % in the pre-2000 era to 11 % in the post-2000 era. This study summarizes diagnostic methods and treatment interventions and prognostication in this rare condition.
胃心包瘘是一种罕见的危及生命的疾病,现代文献中仅报道过65例。
一名67岁男性,出现体重减轻、胸痛和上腹部疼痛,计算机成像检查发现有心包积液和心包积气。内镜检查和组织学检查证实,食管裂孔疝内有胃腺癌,且已形成通向心包的瘘管。他的病情因肺栓塞和肺叶梗死而复杂化,所有这些因素都导致病情迅速恶化并死亡。
回顾所有先前发表的病例发现,预测预后较差的因素包括年龄较大、癌症病因和保守治疗。相反,保护因素包括发病时年龄较轻、先前有胃食管手术史或溃疡作为病因,以及积极的手术和外科治疗。尽管许多临床医生认为这种诊断在很大程度上是致命的,但手术治疗已使死亡率从2000年前的69%显著降至2000年后的11%。本研究总结了这种罕见疾病的诊断方法、治疗干预措施和预后情况。