De Reuck J, Auger F, Durieux N, Deramecourt V, Maurage C-A, Lebert F, Leys D, Cordonnier C, Pasquier F, Bordet R
J.L. De Reuck, Leopold II laan 96, BE-9000, Ghent, Belgium, phone: +32 9 2218844, fax: +32 9 3324971, e-mail:
Folia Neuropathol. 2016;54(2):149-55. doi: 10.5114/fn.2016.60364.
Cerebrovascular lesions are rare in frontotemporal lobar degeneration (FTLD), in contrast to other neurodegenerative diseases. Cortical microbleeds (CoMBs) are frequent in Alzheimer's disease, in particular in cases associated with cerebral amyloid angiopathy. The present study investigates the gyral topographic distribution of CoMBs in post-mortem FTLD brains with 7.0-tesla magnetic resonance imaging.
The distribution of CoMBs in 11 post-mortem FTLD brains and in 12 control brains was compared on T2*-GRE MRI of six coronal sections of a cerebral hemisphere. The mean values of CoMBs were determined in twenty-two different gyri. The findings were correlated to those separately observed on neuropathological examination.
As a whole there was a trend of more CoMBs in the prefrontal section of FTLD as well as of the control brains. CoMBs were significantly increased in the superior frontal gyrus and the insular cortex (p ≤ 0.001) and also in the inferior frontal gyrus and the superior temporal gyrus (p ≤ 0.01).
CoMBs in FTLD are only increased in the regions mainly affected by the neurodegenerative lesions. They probably do not reflect additional cerebrovascular disease.
与其他神经退行性疾病不同，脑血管病变在额颞叶变性（FTLD）中较为罕见。皮质微出血（CoMBs）在阿尔茨海默病中很常见，尤其是在与脑淀粉样血管病相关的病例中。本研究采用7.0特斯拉磁共振成像技术，研究死后FTLD脑内CoMBs的脑回地形分布。
在大脑半球六个冠状切面的T2 * -GRE MRI上，比较11例死后FTLD脑和12例对照脑内CoMBs的分布。在22个不同脑回中测定CoMBs的平均值。将这些发现与神经病理学检查中分别观察到的结果进行关联。
总体而言，FTLD组和对照组的额叶前部CoMBs均有增多趋势。额上回和岛叶皮质的CoMBs显著增加（p≤0.001），额下回和颞上回也显著增加（p≤0.01）。
FTLD中的CoMBs仅在主要受神经退行性病变影响的区域增加。它们可能并不反映额外的脑血管疾病。
