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单纯性急性阑尾炎作为日间手术的管理:可行性及对排除标准和治疗失败的批判性分析

Management of Uncomplicated Acute Appendicitis as Day Case Surgery: Feasibility and a Critical Analysis of Exclusion Criteria and Treatment Failure.

作者信息

Grelpois Gérard, Sabbagh Charles, Cosse Cyril, Robert Brice, Chapuis-Roux Emilie, Ntouba Alexandre, Lion Thierry, Regimbeau Jean-Marc

机构信息

Department of Digestive Surgery, Amiens-Picardie University Medical Center, Amiens, France; Clinical Research Center, Amiens-Picardie University Medical Center, Amiens, France; Department of Digestive Surgery, University of Picardie Jules Verne, Amiens, France; Virology Research Unit, University of Picardie Jules Verne, Amiens, France; Clinical Research Center, University of Picardie Jules Verne, Amiens, France.

Department of Digestive Surgery, Amiens-Picardie University Medical Center, Amiens, France; Department of Digestive Surgery, University of Picardie Jules Verne, Amiens, France; Institut National de la Santé et de la Recherche Médicale UMR-S 1088, University of Picardie Jules Verne, Amiens, France; University of Picardie Jules Verne, Amiens, France.

出版信息

J Am Coll Surg. 2016 Nov;223(5):694-703. doi: 10.1016/j.jamcollsurg.2016.08.004. Epub 2016 Aug 18.

Abstract

BACKGROUND

Day case surgery (DCS) for uncomplicated acute appendicitis (NCAA) is evaluated. The objective of this prospective, single-center, descriptive, nonrandomized, intention-to-treat cohort study was to assess the feasibility of DCS for NCAA with a critical analysis of the reasons for exclusion and treatment failures and a focus on patients discharged to home and admitted for DCS on the following day.

STUDY DESIGN

From April 2013 to December 2015, NCAA patients meeting the inclusion criteria were included in the study. The primary end point was the success rate for DCS (length of stay less than 12 hours) in the intention-to-treat population (all NCAA) and in the per-protocol population (no pre- or perioperative exclusion criteria). The secondary end points were morbidity, DCS quality criteria, predictive factors for successful DCS, patient satisfaction, quality of life, and reasons for pre- or perioperative exclusion. A subgroup of patients discharged to home the day before operation was also analyzed.

RESULTS

A total of 240 patients were included. The success rate of DCS was 31.5% in the intention-to-treat population and 91.5% in the per-protocol population. The rates of unplanned consultations, hospitalization, and reoperation were 13%, 4%, and 1%, respectively. An analysis of the reasons for DCS exclusion showed that 73% could have been modified. For the 68 patients discharged to home on the day before operation, the DCS success rate was 91%.

CONCLUSIONS

Day case surgery is feasible in NCAA. A critical analysis of the reasons for exclusion from DCS showed that it should be possible to dramatically increase the eligible population.

摘要

背景

对非复杂性急性阑尾炎(NCAA)进行日间手术(DCS)进行评估。这项前瞻性、单中心、描述性、非随机、意向性队列研究的目的是评估NCAA行DCS的可行性,对排除原因和治疗失败原因进行批判性分析,并重点关注出院回家和次日因DCS入院的患者。

研究设计

2013年4月至2015年12月,符合纳入标准的NCAA患者纳入研究。主要终点是意向性治疗人群(所有NCAA患者)和符合方案人群(无术前或围手术期排除标准)中DCS的成功率(住院时间少于12小时)。次要终点包括发病率、DCS质量标准、DCS成功的预测因素、患者满意度、生活质量以及术前或围手术期排除的原因。还对术前一天出院回家的患者亚组进行了分析。

结果

共纳入240例患者。意向性治疗人群中DCS的成功率为31.5%,符合方案人群中为91.5%。计划外会诊、住院和再次手术的发生率分别为13%、4%和1%。对DCS排除原因的分析表明,73%的原因是可以改变的。对于术前一天出院回家的68例患者,DCS成功率为91%。

结论

日间手术在NCAA中是可行的。对DCS排除原因的批判性分析表明,有可能大幅增加符合条件的人群。

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