Guan Xiaojun, Xuan Min, Gu Quanquan, Xu Xiaojun, Huang Peiyu, Wang Nian, Shen Zhujing, Xu Jingjing, Luo Wei, Zhang Minming
Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Brain Imaging and Analysis Center, Duke University School of Medicine, Durham, North Carolina, USA.
J Magn Reson Imaging. 2017 May;45(5):1335-1342. doi: 10.1002/jmri.25434. Epub 2016 Aug 22.
Because the roles of striatal-thalamo-cortical and cerebello-thalamo-cortical circuits in the heterogeneous motor impairments of Parkinson's disease (PD) are becoming recognized, this study was designed to investigate the relationships between regional iron in the cardinal subcortical nuclei in these circuits and the different motor impairments.
Sixty-two PD patients and 40 normal subjects were included and accepted for Enhanced T -Star Weighted Angiography Scanning (3.0T). According to the Unified Parkinson's Disease Rating Scale, patients were divided into tremor-dominant (PD-TD) and akinetic/rigid-dominant groups (PD-AR). The intergroup differences of magnetic susceptibility in those cardinal nuclei were measured. Correlation analyses between magnetic susceptibility and motor impairments were performed in all patients.
Nigral magnetic susceptibility significantly increased for each PD group compared with controls (P < 0.001 for PD-TD; P = 0.001 for PD-AR). Magnetic susceptibility in the dentate nucleus (DN) and red nucleus (RN) for the PD-TD patients were significantly increased compared with controls (P < 0.001 and P = 0.004, respectively). Magnetic susceptibility in these regions was also significantly correlated with tremor severity (r = 0.444, P = 0.001 for DN; r = 0.418, P = 0.001 for RN). Significant correlation between caudate magnetic susceptibility and akinetic/rigid severity were observed (r = -0.322, P = 0.015).
This study provides evidence that nigral iron accumulation is a common characteristic in PD, while iron accumulation in the DN and RN is correlated with tremor symptoms. Our data also indicate that caudate iron content may be a potential marker for akinetic/rigid progression.
3 J. MAGN. RESON. IMAGING 2017;45:1335-1342.
鉴于纹状体 - 丘脑 - 皮质和小脑 - 丘脑 - 皮质回路在帕金森病（PD）异质性运动障碍中的作用逐渐得到认可，本研究旨在探讨这些回路中主要皮质下核团的局部铁含量与不同运动障碍之间的关系。
纳入62例PD患者和40例正常受试者，并接受增强T*加权血管造影扫描（3.0T）。根据统一帕金森病评定量表，将患者分为震颤为主型（PD - TD）和运动不能/强直为主型组（PD - AR）。测量这些主要核团的磁化率组间差异。对所有患者进行磁化率与运动障碍之间的相关性分析。
与对照组相比，各PD组黑质磁化率显著升高（PD - TD组P < 0.001；PD - AR组P = 0.001）。与对照组相比，PD - TD患者齿状核（DN）和红核（RN）的磁化率显著升高（分别为P < 0.001和P = 0.004）。这些区域的磁化率也与震颤严重程度显著相关（DN：r = 0.444，P = 0.001；RN：r = 0.418，P = 0.001）。观察到尾状核磁化率与运动不能/强直严重程度之间存在显著相关性（r = -0.322，P = 0.015）。
本研究提供了证据表明黑质铁蓄积是PD的一个共同特征，而DN和RN中的铁蓄积与震颤症状相关。我们的数据还表明尾状核铁含量可能是运动不能/强直进展的一个潜在标志物。
3 J. MAGN. RESON. IMAGING 2017;45:1335 - 1342。
