Kim Jong Dai, Lee Won Young
Division of Endocrinology and Metabolism, Department of Internal Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Endocrinol Metab (Seoul). 2016 Sep;31(3):354-360. doi: 10.3803/EnM.2016.31.3.354. Epub 2016 Aug 16.
It is well known that many Korean patients with type 2 diabetes mellitus (T2DM) were non-obese and had decreased insulin secretion in past. However, during the past three decades, lifestyles in Korea have been westernized. As a result, the prevalence of obesity, the main cause of diabetes has increased. Thus, there is still a question as to whether the main pathophysiology of current Korean T2DM is insulin resistance or an insulin secretion defect. Because various anti-diabetes medications having different mechanisms of action are currently used as therapeutics, it is important to understand which of these factors is the main physiology in the development of diabetes in Koreans. In this review, we review changes in obesity prevalence, insulin resistance and insulin secretion defects in Korean T2DM during three decades.
众所周知，过去许多韩国2型糖尿病（T2DM）患者并非肥胖，且胰岛素分泌减少。然而，在过去三十年里，韩国人的生活方式已经西化。结果，作为糖尿病主要病因的肥胖症患病率有所上升。因此，目前韩国T2DM的主要病理生理学是胰岛素抵抗还是胰岛素分泌缺陷仍是一个问题。由于目前使用了具有不同作用机制的各种抗糖尿病药物作为治疗手段，了解这些因素中哪一个是韩国人糖尿病发病的主要生理因素很重要。在这篇综述中，我们回顾了三十年来韩国T2DM患者肥胖患病率、胰岛素抵抗和胰岛素分泌缺陷的变化。
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