Mendoza Erick S, Lopez Amy A, Valdez Valerie Ann U, Mercado-Asis Leilani B
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Santo Tomas Hospital, Manila, Philippines.
Endocrinol Metab (Seoul). 2016 Sep;31(3):433-438. doi: 10.3803/EnM.2016.31.3.433. Epub 2016 Aug 16.
Osteoporosis in men is markedly underdiagnosed and undertreated despite higher morbidity and mortality associated with fractures. This study aimed to characterize adult Filipino men with osteopenia, osteoporosis and prevalent fractures.
A cross-sectional study of 184 Filipino men ≥50 years screened for bone mineral density was performed. Age, weight, body mass index (BMI), Osteoporosis Self-Assessment Tool for Asians (OSTA) score, smoking status, family history of fracture, diabetes mellitus, physical inactivity, and T-score were considered.
Of the 184 patients, 40.2% and 29.9% have osteopenia and osteoporosis. Sixteen (21.6%) and 18 (32.1%) osteopenic and osteoporotic men have fragility hip, spine, or forearm fractures. Men aged 50 to 69 years have the same risk of osteoporosis and fractures as those ≥70 years. While hip fractures are higher in osteoporotic men, vertebral fractures are increased in both osteopenic and osteoporotic men. Mere osteopenia predicts the presence of prevalent fractures. A high risk OSTA score can predict fracture. A BMI <21 kg/m² (P<0.05) and current smoking are associated with osteoporosis.
A significant fraction of Filipino men with osteopenia and osteoporosis have prevalent fractures. Our data suggest that fractures occur in men <70 years even before osteoporosis sets in. Low BMI, high OSTA score, and smoking are significant risk factors of osteoporosis.
尽管男性骨质疏松症与骨折相关的发病率和死亡率较高,但仍明显存在诊断不足和治疗不足的情况。本研究旨在对患有骨质减少、骨质疏松症和有既往骨折史的成年菲律宾男性进行特征描述。
对184名年龄≥50岁的菲律宾男性进行了骨密度筛查的横断面研究。考虑了年龄、体重、体重指数(BMI)、亚洲人骨质疏松自我评估工具(OSTA)评分、吸烟状况、骨折家族史、糖尿病、缺乏身体活动以及T值。
在184名患者中,40.2%患有骨质减少,29.9%患有骨质疏松症。16名(21.6%)骨质减少男性和18名(32.1%)骨质疏松男性有髋部、脊柱或前臂脆性骨折。50至69岁男性患骨质疏松症和骨折的风险与70岁及以上男性相同。虽然骨质疏松男性的髋部骨折发生率较高,但骨质减少和骨质疏松男性的椎体骨折发生率均有所增加。单纯的骨质减少可预测既往骨折的存在。高风险OSTA评分可预测骨折。BMI<21kg/m²(P<0.05)和当前吸烟与骨质疏松症相关。
很大一部分患有骨质减少和骨质疏松症的菲律宾男性有既往骨折史。我们的数据表明,在骨质疏松症发生之前甚至在70岁以下的男性中就会发生骨折。低BMI、高OSTA评分和吸烟是骨质疏松症的重要危险因素。