2型糖尿病与老年人：降糖药物的最新进展

Type 2 Diabetes Mellitus and the Elderly: An Update on Drugs Used to Treat Glycaemia.

作者信息

Mitrakou Asimina, Katsiki Niki, Lalic Nebojsa M

机构信息

Department of Clinical Therapeutics, Diabetes and Metabolism Unit, National and Kapodistrian University of Athens, Athens, Greece.

出版信息

Curr Vasc Pharmacol. 2017;15(1):19-29. doi: 10.2174/1570161114666160822154816.

DOI:10.2174/1570161114666160822154816

PMID:27550054

Abstract

Type 2 Diabetes Mellitus (T2DM) and its complications are more prevalent in the elderly. As the general population worldwide is ageing, effective and safe treatment of older T2DM patients is becoming more important in clinical practice. Elderly T2DM patients should be carefully evaluated for functional, mental, geriatric and medical disorders before the initiation of antidiabetic drug therapy and regularly monitored thereafter. Treatment strategy and goals should be individualized based on patient comorbidities and drug pharmacokinetic and pharmacodynamic properties. This narrative review discusses the use of antidiabetic drugs in the elderly T2DM population.

摘要

2型糖尿病（T2DM）及其并发症在老年人中更为普遍。随着全球总人口老龄化，老年T2DM患者的有效且安全的治疗在临床实践中变得越发重要。在开始抗糖尿病药物治疗前，应对老年T2DM患者的功能、精神、老年病学及医学病症进行仔细评估，并在此后定期监测。治疗策略和目标应根据患者的合并症以及药物的药代动力学和药效学特性进行个体化制定。本叙述性综述讨论了抗糖尿病药物在老年T2DM人群中的应用。