2型糖尿病的药物治疗：最新进展
Pharmacotherapy of type 2 diabetes: An update.
作者信息
Upadhyay Jagriti, Polyzos Stergios A, Perakakis Nikolaos, Thakkar Bindiya, Paschou Stavroula A, Katsiki Niki, Underwood Patricia, Park Kyung-Hee, Seufert Jochen, Kang Eun Seok, Sternthal Elliot, Karagiannis Asterios, Mantzoros Christos S
机构信息
Section of Endocrinology, Diabetes and Metabolism, Boston VA Healthcare System, Boston, MA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
First Department of Pharmacology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
出版信息
Metabolism. 2018 Jan;78:13-42. doi: 10.1016/j.metabol.2017.08.010. Epub 2017 Sep 8.
Type 2 diabetes (T2DM) is a leading cause of morbidity and mortality worldwide and a major economic burden. The prevalence of T2DM is rising, suggesting more effective prevention and treatment strategies are necessary. The aim of this narrative review is to summarize the pharmacologic treatment options available for patients with T2DM. Each therapeutic class is presented in detail, outlining medication effects, side effects, glycemic control, effect on weight, indications and contraindications, and use in selected populations (heart failure, renal insufficiency, obesity and the elderly). We also present representative cost for each antidiabetic category. Then, we provide an individualized guide for initiation and intensification of treatment and discuss the considerations and rationale for an individualized glycemic goal.
2型糖尿病（T2DM）是全球发病和死亡的主要原因，也是一项重大的经济负担。T2DM的患病率正在上升，这表明需要更有效的预防和治疗策略。本叙述性综述的目的是总结T2DM患者可用的药物治疗选择。详细介绍了每个治疗类别，概述了药物作用、副作用、血糖控制、对体重的影响、适应症和禁忌症以及在特定人群（心力衰竭、肾功能不全、肥胖和老年人）中的使用情况。我们还列出了每种抗糖尿病药物类别的代表性成本。然后，我们提供了一份治疗起始和强化的个性化指南，并讨论了个体化血糖目标的考虑因素和基本原理。
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