Current questions and controversies in chromosome fragile site research: does WWOX, the gene product of common fragile site FRA16D, have a passive or active role in cancer?
作者信息
Hazan I, Aqeilan R I
机构信息
Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School , Jerusalem, Israel.
出版信息
Cell Death Discov. 2015 Oct 19;1:15040. doi: 10.1038/cddiscovery.2015.40. eCollection 2015.
Abstract
摘要
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The fragile site WWOX gene and the developing brain.
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WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response.
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WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma.
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