Kontos G J, Schaff H V, Gersh B J, Bove A A
Section of Thoracic and Cardiovascular Surgery, Mayo Clinic, Rochester, Minn. 55905.
J Thorac Cardiovasc Surg. 1989 Aug;98(2):163-9.
Quantitative analysis of biplane ventriculograms, including calculation of the end-systolic pressure/volume ratio, was used to define left ventricular systolic performance in 10 normal subjects, 10 patients with symptomatic subacute (less than 6 months' duration) mitral regurgitation, and 18 patients with symptomatic chronic mitral regurgitation. Left ventricular volume, mass, and systolic function were similar for patients with subacute and with chronic mitral regurgitation, suggesting that some patients with recent-onset nonischemic mitral regurgitation have partial adaptation to chronic valve insufficiency prior to their symptomatic event. Rate of development of left ventricular wall stress in early systole was increased in subacute mitral regurgitation compared with chronic mitral regurgitation and normal subjects. Duration of symptoms did not correlate with degree of ventricular adaptation to mitral regurgitation, and end-systolic indices of left ventricular performance did not predict early postoperative clinical response to valve replacement or repair.
对双平面心室造影进行定量分析，包括计算收缩末期压力/容积比值，以定义10名正常受试者、10名有症状的亚急性（病程小于6个月）二尖瓣反流患者和18名有症状的慢性二尖瓣反流患者的左心室收缩功能。亚急性和慢性二尖瓣反流患者的左心室容积、质量和收缩功能相似，这表明一些近期发生非缺血性二尖瓣反流的患者在出现症状之前已对慢性瓣膜功能不全有部分适应。与慢性二尖瓣反流患者和正常受试者相比，亚急性二尖瓣反流患者在收缩早期左心室壁应力的发展速率增加。症状持续时间与心室对二尖瓣反流的适应程度无关，左心室收缩功能的末期指标也不能预测瓣膜置换或修复术后的早期临床反应。
