维生素D受体基因多态性与儿童哮喘易感性的关联：一项荟萃分析。
Association of vitamin D receptor gene polymorphisms with susceptibility to childhood asthma: A meta-analysis.
作者信息
Zhao Dong-Dong, Yu Dan-Dan, Ren Qiong-Qiong, Dong Bao, Zhao Feng, Sun Ye-Huan
机构信息
Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei, China.
Centre for Evidence-Based Practice, Anhui Medical University, Hefei, China.
出版信息
Pediatr Pulmonol. 2017 Apr;52(4):423-429. doi: 10.1002/ppul.23548. Epub 2016 Aug 23.
BACKGROUND
As for the association of vitamin D receptor (VDR) gene polymorphisms with susceptibility to pediatric asthma, results of published studies yielded conflicts. A systematic review was conducted on the relationship between childhood asthma and VDR gene polymorphisms, including ApaI (rs7975232), BsmI (rs1544410), FokI (rs2228570), and TaqI (rs731236).
METHODS
PubMed, Web of Science, CBM (Chinese Biomedical Database), CNKI (China National Knowledge Infrastructure), and Wanfang (Chinese) database were searched for relevant studies. Pooled odds ratios (OR) with 95% confidence interval (CI) were calculated.
RESULTS
Overall results suggested that there was a statistically significant association between ApaI polymorphism and childhood asthma in homozygote model (OR = 1.674, 95%CI = 1.269-2.208, P < 0.001) and allele model (OR = 1.221, 95%CI = 1.084-1.375, P = 0.001). Stratification by ethnicity revealed a statistical association in Asians (OR = 1.389, 95%CI = 1.178-1.638, P < 0.001). There was some evidence of an association between BsmI polymorphism and childhood asthma in the homozygote (OR = 1.462, 95%CI = 1.016-2.105, P = 0.041) and allele models (OR = 1.181, 95%CI = 1.006-1.386, P = 0.042). This association reached significance only in the Caucasian group (OR = 1.236, 95%CI = 1.029-1.485, P = 0.023). For FokI, a statistical association was detected in dominant model (OR = 1.281, 95%CI = 1.055-1.555, P = 0.012); this association was significant in allele model (OR = 1.591, 95%CI = 1.052-2.405, P = 0.028) in Caucasian.
CONCLUSION
ApaI polymorphism plays a particular role in childhood asthma in Asians. FokI polymorphism may be connected with pediatric asthma in Caucasian population. And BsmI polymorphism marginally contributes to childhood asthma susceptibility, while there might be no association between TaqI polymorphism and childhood asthma risk. Pediatr Pulmonol. 2017;52:423-429. © 2016 Wiley Periodicals, Inc.
背景
关于维生素D受体（VDR）基因多态性与儿童哮喘易感性的关联，已发表研究的结果存在冲突。本研究对儿童哮喘与VDR基因多态性（包括ApaI（rs7975232）、BsmI（rs1544410）、FokI（rs2228570）和TaqI（rs731236））之间的关系进行了系统评价。
方法
检索PubMed、Web of Science、CBM（中国生物医学数据库）、CNKI（中国知网）和万方（中文）数据库中的相关研究。计算合并比值比（OR）及95%置信区间（CI）。
结果
总体结果表明，在纯合子模型（OR = 1.674，95%CI = 1.269 - 2.208，P < 0.001）和等位基因模型（OR = 1.221，95%CI = 1.084 - 1.375，P = 0.001）中，ApaI多态性与儿童哮喘之间存在统计学显著关联。按种族分层显示，在亚洲人中存在统计学关联（OR = 1.389，95%CI = 1.178 - 1.638，P < 0.001）。有证据表明，在纯合子（OR = 1.462，95%CI = 1.016 - 2.105，P = 0.041）和等位基因模型（OR = 1.181，95%CI = 1.006 - 1.386，P = 0.042）中，BsmI多态性与儿童哮喘之间存在关联。这种关联仅在白种人群中具有统计学意义（OR = 1.236，95%CI = 1.029 - 1.485，P = 0.023）。对于FokI，在显性模型中检测到统计学关联（OR = 1.281，95%CI = 1.055 - 1.555，P = 0.012）；在白种人的等位基因模型中这种关联具有统计学意义（OR = 1.591，95%CI = 1.052 - 2.405，P = 0.028）。
结论
ApaI多态性在亚洲儿童哮喘中起特定作用。FokI多态性可能与白种人群的儿童哮喘有关。BsmI多态性对儿童哮喘易感性有一定作用，而TaqI多态性与儿童哮喘风险可能无关。《儿科肺脏病学》。2017；52：423 - 429。© 2016威利期刊公司
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