Agra Isabela K R, Brizot Maria L, Miyadahira Mariana Y, Carvalho Mário H B, Francisco Rossana P V, Zugaib Marcelo
Department of Obstetrics and Gynaecology, São Paulo University Medical School, Brazil.
Department of Obstetrics and Gynaecology, São Paulo University Medical School, Brazil.
Eur J Obstet Gynecol Reprod Biol. 2016 Oct;205:11-4. doi: 10.1016/j.ejogrb.2016.08.016. Epub 2016 Aug 10.
This study investigated the influence of vaginal progesterone on uterine circulation in asymptomatic twin gestations.
This study was a secondary analysis of a randomized, double-blind, placebo-controlled trial of twin pregnancies exposed to vaginal progesterone or placebo. We included all trial participants who had undergone uterine artery pulsatility index evaluation at the time of randomization. During each ultrasound examination, the uterine artery pulsatility index was evaluated transabdominally. The mean uterine artery pulsatility index between the progesterone and placebo groups were compared for each gestational age, starting between 18 to 34 weeks and 6days and were analyzed at three (Time 1), six (Time 2) and nine (Time 3) weeks after randomization.
The final analysis included 128 women in the progesterone group and 122 women in the placebo group. The baseline characteristics were similar in both groups. No difference in the mean uterine artery pulsatility index was observed between the progesterone and placebo groups at each week of gestation or throughout gestation.
In twin pregnancies, the use of vaginal progesterone in the second half of pregnancy does not influence uterine circulation.
本研究调查了阴道用黄体酮对无症状双胎妊娠子宫循环的影响。
本研究是一项对双胎妊娠随机、双盲、安慰剂对照试验的二次分析，试验对象为接受阴道用黄体酮或安慰剂的孕妇。我们纳入了所有在随机分组时接受过子宫动脉搏动指数评估的试验参与者。在每次超声检查时，经腹评估子宫动脉搏动指数。比较黄体酮组和安慰剂组在每个孕周（从18周零6天开始）的平均子宫动脉搏动指数，并在随机分组后的3周（时间1）、6周（时间2）和9周（时间3）进行分析。
最终分析纳入了黄体酮组的128名女性和安慰剂组的122名女性。两组的基线特征相似。在妊娠的每个孕周或整个妊娠期，黄体酮组和安慰剂组的平均子宫动脉搏动指数均未观察到差异。
在双胎妊娠中，妊娠后半期使用阴道用黄体酮不会影响子宫循环。
