Ho Grace, Clarke Russell C, Sadleir Paul H M, Platt Peter R
From the *Department of Anesthesia, Sir Charles Gairdner Hospital, Nedlands, Australia; ‡Department of Pharmacology, University of Western Australia, Crawley, Western Australia, Australia; and †Anesthetic Allergy Referral Centre of Western Australia, Nedlands, Western Australia, Australia.
A A Case Rep. 2016 Nov 1;7(9):190-192. doi: 10.1213/XAA.0000000000000382.
A 50-year-old man developed a severe anaphylactic reaction shortly after the administration of sugammadex at the end of an uneventful laparoscopic appendectomy. Subsequent skin testing was negative to all agents to which the patient was exposed including sugammadex. Because of the temporal relationship to the administration of sugammadex, further skin testing was performed with premixed sugammadex and rocuronium that produced a markedly positive response. This is the first case report of anergy to the individual components but sensitivity to the inclusion complex of rocuronium and sugammadex. Written informed consent was obtained from the patient for skin testing, photography, laser perfusion imaging, and publication of this case report.
一名50岁男性在顺利完成腹腔镜阑尾切除术后使用舒更葡糖钠后不久发生严重过敏反应。随后的皮肤试验对患者接触过的所有药物（包括舒更葡糖钠）均呈阴性。由于与舒更葡糖钠给药存在时间关联，遂用预混的舒更葡糖钠和罗库溴铵进行进一步皮肤试验，结果呈明显阳性反应。这是首例对各成分无反应但对罗库溴铵与舒更葡糖钠包合物敏感的病例报告。已获得患者关于皮肤试验、摄影、激光灌注成像及发表本病例报告的书面知情同意。
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