成功应用琥珀酰明胶治疗罗库溴铵诱导的过敏反应：一例报告。
Successful management of rocuronium-induced anaphylactic reactions with sugammadex: a case report.
机构信息
Department of Anesthesiology and Critical Care Medicine, Kochi Medical School, Kochi, 783-8505, Japan.
出版信息
J Clin Anesth. 2012 Feb;24(1):62-4. doi: 10.1016/j.jclinane.2011.04.015. Epub 2011 Dec 6.
Sugammadex, a new reversal agent for rocuronium, encapsulates the rocuronium molecule and results in rapid reversal of rocuronium-induced neuromuscular blockade. A case in which sugammadex was used to treat an anaphylactic reaction that occurred after rocuronium is presented. The binding/encapsulation of rocuronium by sugammadex may selectively eliminate the antigenic quaternary ammonium activity of circulating rocuronium, and prevent the propagation of rocuronium-induced anaphylaxis.
苏伽[达]，一种罗库溴铵的新型逆转剂，包裹罗库溴铵分子，导致罗库溴铵诱导的神经肌肉阻滞迅速逆转。本文报告了一例苏伽[达]用于治疗罗库溴铵后发生的过敏反应的病例。苏伽[达]与罗库溴铵的结合/包裹可能选择性地消除循环罗库溴铵的抗原性季铵活性，从而防止罗库溴铵诱导的过敏反应的传播。
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