Ruiz Manzano J, Parra O, Roig J, Manterola J, Abad J, Morera J
Med Clin (Barc). 1989 Apr 22;92(15):561-3.
We have evaluated the close contacts of 191 patients diagnosed of tuberculosis in our center between 1984 and 1987. The overall number of evaluated contacts was 666, and the mean number of contacts for each index case was 3.7. In 55% of the evaluated population PPD reaction was positive, and their mean age was 33.3 years. In 132 cases chemoprophylaxis was given during one year (22%). Forty-one new cases of tuberculosis were detected, with a mean age of 25.6 years. In ten new cases the source of infection was familial. When the contacts were distributed according to the bacteriologic status of the index case (direct investigation of tubercle bacilli positive in 103 cases and negative in 167), the rate of disease and infection was significantly higher among those related to positive patients. In the group related to negative patients we discovered 7 new cases of active tuberculosis. Our results confirm the usefulness of the systematic evaluation of the contacts of tuberculous patients in our area, as it permits the identification of an important number of new patients which should be adequately treated. This practice contributes to interrupt the epidemiologic transmission chain of the disease and to facilitate its eradication.
我们对1984年至1987年间在本中心确诊为结核病的191例患者的密切接触者进行了评估。评估的接触者总数为666人，每例索引病例的平均接触者人数为3.7人。在55%的评估人群中，PPD反应呈阳性，他们的平均年龄为33.3岁。132例（22%）在一年内接受了化学预防。发现了41例新的结核病病例，平均年龄为25.6岁。10例新病例的感染源为家庭内感染。当根据索引病例的细菌学状况对接触者进行分类时（103例结核杆菌直接检测呈阳性，167例呈阴性），与阳性患者相关的接触者中疾病和感染率明显更高。在与阴性患者相关的组中，我们发现了7例活动性结核病新病例。我们的结果证实了对本地区结核病患者接触者进行系统评估的有效性，因为这有助于识别大量应得到适当治疗的新患者。这种做法有助于中断疾病的流行病学传播链并促进其根除。
