肺炎克雷伯菌 ST258 中对黏菌素敏感和耐药的 MgrB 变异体。
MgrB variants in colistin-susceptible and colistin-resistant Klebsiella pneumoniae ST258.
机构信息
Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary.
Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary.
出版信息
J Microbiol Immunol Infect. 2017 Oct;50(5):735-736. doi: 10.1016/j.jmii.2016.06.008. Epub 2016 Jul 29.
PMID:27553451
Abstract
Resistance determinants of a colistin susceptible and five colistin resistant Klebsiella pneumoniae ST258 from a Hungarian outbreak were investigated. A novel MgrB variant in colistin susceptible strain was found. Elevated phoP and arn gene expressions and wild-type PmrB in all colistin resistant K. pneumoniae were detected. All strains lacked mcr-1.
摘要
研究了源自匈牙利疫情的一株对黏菌素敏感和五株对黏菌素耐药的肺炎克雷伯菌 ST258 的耐药决定因素。在对黏菌素敏感的菌株中发现了一种新型MgrB 变体。所有对黏菌素耐药的肺炎克雷伯菌的 phoP 和 arn 基因表达升高，且 PmrB 为野生型。所有菌株均不携带 mcr-1。
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