血清 betatrophin 水平与葡萄糖刺激的胰岛素分泌第一时相之间的关系。

Relationship between serum betatrophin levels and the first-phase of glucose-stimulated insulin secretion.

机构信息

Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

出版信息

Obes Res Clin Pract. 2018 Jan-Feb;12(Suppl 2):9-15. doi: 10.1016/j.orcp.2016.08.004. Epub 2016 Aug 21.

DOI:10.1016/j.orcp.2016.08.004

PMID:27554132

Abstract

AIMS

To examine circulating betatrophin concentrations in subjects with different glucose tolerance status and to investigate the relationship between serum betatrophin levels and first-phase of glucose-stimulated insulin secretion.

METHODS

Serum betatrophin concentrations were measured in 110 age- and sex-matched subjects: 47 newly diagnosed type 2 diabetes mellitus (T2DM), 29 impaired glucose tolerance (IGT) and 34 normal glucose tolerance (NGT). Oral glucose tolerance test and intravenous glucose tolerance test were performed to assess glucose tolerance and first-phase of glucose-stimulated insulin secretion.

RESULTS

Serum betatrophin levels were significantly higher in the T2DM and IGT group than in the NGT group (2.10±1.16ng/mL vs 0.77±0.44ng/mL, 1.73±1.28ng/mL vs 0.77±0.44ng/mL; P<0.01). The AIR and AUC among the three groups showed a progressive decrease from the NGT to IGT group with the lowest value in the T2DM group (P<0.01). Betatrophin were found to be positively correlated with BMI, waist circumference (WC), homeostatic model assessment of insulin resistance (HOMA-IR) and triglyceride (TG), and inversely associated with HDL-c (all P<0.01), but not significantly correlated with 0-10min insulin the area under the curve (AUC) and acute insulin response (AIR) (P>0.05). Stepwise multiple regression analysis showed that HOMA-IR and TG were independently related to betatrophin (P<0.05).

CONCLUSION

Serum betatrophin concentrations were higher in T2DM and IGT, and were closely related to glucolipid disorder, insulin resistance, but not related to the first-phase of glucose-stimulated insulin secretion.

摘要

目的

检测不同糖代谢状态人群血清中 betatrophin 浓度，探讨其与胰岛β细胞第一时相胰岛素分泌的关系。

方法

选择年龄、性别相匹配的 110 例受试者，其中新诊断的 2 型糖尿病（T2DM）患者 47 例，糖调节受损（IGT）患者 29 例，正常糖耐量（NGT）者 34 例，分别检测其血清 betatrophin 浓度，并行口服葡萄糖耐量试验和静脉葡萄糖耐量试验以评估其糖代谢和胰岛β细胞第一时相胰岛素分泌功能。

结果

T2DM 组和 IGT 组患者血清 betatrophin 水平均显著高于 NGT 组（2.10±1.16ng/mL 比 0.77±0.44ng/mL，1.73±1.28ng/mL 比 0.77±0.44ng/mL；P<0.01），三组人群胰岛素分泌第一时相（AIR）和曲线下面积（AUC）均逐渐下降，T2DM 组最低（P<0.01）。Spearman 相关分析显示，血清 betatrophin 水平与 BMI、腰围（WC）、稳态模型评估的胰岛素抵抗指数（HOMA-IR）、三酰甘油（TG）呈正相关（均 P<0.01），与高密度脂蛋白胆固醇（HDL-c）呈负相关（均 P<0.01），与 0-10min 胰岛素 AUC 和 AIR 无相关性（P>0.05）。多元逐步回归分析显示，HOMA-IR 和 TG 与 betatrophin 独立相关（P<0.05）。