Lee Seung Hoon, Jung Kyu-Won, Ha Johyun, Oh Chang-Mo, Kim Hyeseon, Park Hyeon Jin, Yoo Heon, Won Young-Joo
Neuro-Oncology Clinic, National Cancer Center, Goyang, Korea.
Department of Neurosurgery, Eulji University School of Medicine, Daejeon, Korea.
Cancer Res Treat. 2017 Apr;49(2):494-501. doi: 10.4143/crt.2016.129. Epub 2016 Aug 24.
Malignant central nervous system (CNS) germ cell tumors (GCTs), although rare, are thought to occur more frequently among Asians. However, a recent population-based study revealed no differences in GCT incidence between Asians and Caucasians. Therefore, this study was conducted to determine the incidence and survival rates of CNS GCTs using the national cancer incidence database, and to compare these rates to those in the United States and Japan.
We extracted CNS GCT patients diagnosed between 2005 and 2012 from the Korea Central Cancer Registry database. Age-standardized rates (ASRs), annual percentage change, and the male-female incidence rate ratios (IRRs) were calculated. To estimate the survival rate, we used data for patients diagnosed between 2005 and 2010 and followed their cases until December 31, 2013.
The ASR for CNS GCT between 2005 and 2012 was 0.179 per 100,000 (95% confidence interval, 0.166 to 0.193), with an overall male-to-female (M:F) IRR of 2.95:1. However, when stratified by site, the M:F IRR was 13.62:1 for tumors of the pineal region and 1.87:1 for those located in nonpineal regions. The most frequent histologic type was germinoma (76.0%), and the most frequent location was the suprasellar region (48.5%). The 5-year survival rate of germinoma patients was 95.3%.
The incidence rate of CNS GCTs in Korea during 2005-2012 was 0.179 per 100,000, which was similar to that of the Asian/Pacific Islander subpopulation in the United States. Moreover, the CNS GCT survival rate in Korea was similar to rates in Japan and the United States.
恶性中枢神经系统(CNS)生殖细胞肿瘤(GCTs)虽然罕见,但被认为在亚洲人中更为常见。然而,最近一项基于人群的研究显示,亚洲人和白种人之间GCT的发病率并无差异。因此,本研究利用国家癌症发病率数据库来确定CNS GCT的发病率和生存率,并将这些比率与美国和日本的进行比较。
我们从韩国中央癌症登记数据库中提取了2005年至2012年间诊断为CNS GCT的患者。计算年龄标准化率(ASRs)、年变化百分比以及男女发病率比(IRRs)。为了估计生存率,我们使用了2005年至2010年间诊断的患者数据,并追踪他们的病例直至2013年12月31日。
2005年至2012年间CNS GCT的ASR为每10万人0.179(95%置信区间,0.166至0.193),总体男女发病率比(M:F)为2.95:1。然而,按部位分层时,松果体区肿瘤的M:F发病率比为13.62:1,非松果体区肿瘤的为1.87:1。最常见的组织学类型是生殖细胞瘤(76.0%),最常见的部位是鞍上区(48.5%)。生殖细胞瘤患者的5年生存率为95.3%。
2005 - 2012年韩国CNS GCT的发病率为每10万人0.179,与美国亚洲/太平洋岛民亚人群的发病率相似。此外,韩国CNS GCT的生存率与日本和美国的相似。