Balivada Sivasai, Pawar Hitesh N, Montgomery Shawnee, Kenney Michael J
Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Department of Biological Sciences, College of Science, University of Texas at El Paso, El Paso, TX 79968, United States.
Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Department of Biological Sciences, College of Science, University of Texas at El Paso, El Paso, TX 79968, United States.
Auton Neurosci. 2016 Dec;201:68-71. doi: 10.1016/j.autneu.2016.08.011. Epub 2016 Aug 19.
Ghrelin influences immune system function and modulates the sympathetic nervous system; however, the contribution of ghrelin to neural-immune interactions is not well-established because the effect of ghrelin on splenic sympathetic nerve discharge (SND) is not known. This study tested the hypothesis that central ghrelin administration would inhibit splenic SND in anesthetized rats. Rats received intracerebroventricular (ICV) injections of ghrelin (1nmol/kg) or aCSF. Lumbar SND recordings provided a non-visceral nerve control. The ICV ghrelin administration significantly increased splenic and lumbar SND, whereas mean arterial pressure (MAP) was not altered. These findings provide fundamental information regarding the nature of sympathetic-immune interactions.
胃饥饿素影响免疫系统功能并调节交感神经系统；然而，胃饥饿素对神经 - 免疫相互作用的贡献尚未明确，因为胃饥饿素对脾交感神经放电（SND）的影响尚不清楚。本研究检验了以下假设：向麻醉大鼠脑室内注射胃饥饿素会抑制脾SND。大鼠接受脑室内（ICV）注射胃饥饿素（1nmol/kg）或人工脑脊液（aCSF）。腰段SND记录提供了一个非内脏神经对照。脑室内注射胃饥饿素显著增加了脾和腰段SND，而平均动脉压（MAP）未改变。这些发现提供了有关交感 - 免疫相互作用本质的基础信息。
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