McMurphy R M, Fels R J, Kenney M J
Department of Clinical Sciences, Kansas State University, Manhattan, KS, United States.
Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, United States.
Auton Neurosci. 2015 Jul;190:53-7. doi: 10.1016/j.autneu.2015.03.001. Epub 2015 Mar 14.
Sedatives influence the immune system and centrally-acting alpha2-adrenergic receptor agonists, including Dexmedetomidine (Dex), modulate sympathetic nerve discharge (SND). Because sedatives are used under medical conditions that include elderly patients, and because advancing age attenuates SND responsivity to various interventions, we tested the hypothesis that splenic sympathoinhibitory responses to Dex would be attenuated in aged compared with young Fischer 344 rats. Dex-mediated reductions in splenic SND were similar in aged and young baroreceptor-intact and -denervated rats, indicating that SND changes to Dex administration occur in an age-independent manner. These findings provide new information regarding interactions between alpha2-adrenergic agonists, advanced age, and SND regulation.
镇静剂会影响免疫系统，而包括右美托咪定（Dex）在内的中枢作用α2肾上腺素能受体激动剂可调节交感神经放电（SND）。由于镇静剂是在包括老年患者在内的医疗条件下使用的，并且随着年龄的增长，SND对各种干预的反应性会减弱，因此我们检验了这样一个假设：与年轻的Fischer 344大鼠相比，老年大鼠脾脏对Dex的交感神经抑制反应会减弱。在老年和年轻的压力感受器完整和去神经大鼠中，Dex介导的脾脏SND降低相似，这表明给予Dex后SND的变化与年龄无关。这些发现提供了关于α2肾上腺素能激动剂、高龄和SND调节之间相互作用的新信息。
