男性异常基因家族21（Mab21）成员调控眼睛发育。
The Male Abnormal Gene Family 21 (Mab21) Members Regulate Eye Development.
作者信息
Huang Z-X, Xiang J-W, Zhou L, Nie Q, Wang L, Chen Z-G, Hu X-H, Xiao Y, Qing W-J, Liu Y-F, Sun Q, Tang X-C, Liu F-Y, Luo Z-W, Liu W-B, Li D W-C
机构信息
Key Laboratory of Protein Chemistry and Developmental Biology of Educational Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China.
出版信息
Curr Mol Med. 2016;16(7):660-667. doi: 10.2174/1566524016666160824150729.
The male abnormal gene family contains 3 members, named mab21l1, mab21l2 and mab21l3. Since their first discovery in C. elegans, homologues of mab21l1 and mab21l2 have been found in Drosophila, Zebrafish, Xenopus, chicken, mouse and human. A number of studies have revealed that mab21 gene family members, mab21l1 and mab21l2, play important roles in regulating eye development. Here, we review the functions of the mab genes in regulating ocular development.
雄性异常基因家族包含3个成员，分别命名为mab21l1、mab21l2和mab21l3。自它们首次在秀丽隐杆线虫中被发现以来，已在果蝇、斑马鱼、非洲爪蟾、鸡、小鼠和人类中发现了mab21l1和mab21l2的同源物。大量研究表明，mab21基因家族成员mab21l1和mab21l2在调节眼睛发育中发挥重要作用。在此，我们综述了mab基因在调节眼部发育中的功能。
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