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质子治疗在乳腺癌中的新应用。

Novel applications of proton therapy in breast carcinoma.

作者信息

Cuaron John J, MacDonald Shannon M, Cahlon Oren

机构信息

Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Massachusetts General Hospital, Francis H. Burr Proton Therapy Center, Boston, MA 02114-7250, USA.

出版信息

Chin Clin Oncol. 2016 Aug;5(4):52. doi: 10.21037/cco.2016.06.04.

DOI:10.21037/cco.2016.06.04
PMID:27558253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5557715/
Abstract

This review will focus on the indications, clinical experience, and technical considerations of proton beam radiation therapy in the treatment of patients with breast cancer. For patients with early stage disease, proton therapy delivers less dose to non-target breast tissue for patients receiving partial breast irradiation (PBI) therapy, which may result in improved cosmesis but requires further investigation. For patients with locally advanced breast cancer requiring treatment to the regional lymph nodes, proton therapy allows for an improved dosimetric profile compared with conventional photon and electron techniques. Early clinical results demonstrate acceptable toxicity. The possible reduction in cardiopulmonary events as a result of reduced dose to organs at risk will be tested in a randomized control trial of protons vs. photons.

摘要

本综述将聚焦于质子束放射治疗在乳腺癌患者治疗中的适应症、临床经验及技术考量。对于早期疾病患者，质子治疗在接受部分乳腺照射（PBI）治疗的患者中，对非靶区乳腺组织的剂量更低，这可能会改善美容效果，但仍需进一步研究。对于需要对区域淋巴结进行治疗的局部晚期乳腺癌患者，与传统光子和电子技术相比，质子治疗可实现更好的剂量分布。早期临床结果显示毒性可接受。在质子与光子的随机对照试验中，将测试因对危及器官的剂量降低而可能减少的心肺事件。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bcb/5557715/d22c860823df/nihms882129f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bcb/5557715/8fe502c91b50/nihms882129f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bcb/5557715/a52476171adf/nihms882129f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bcb/5557715/5bd30a1cbb0d/nihms882129f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bcb/5557715/3755d392319a/nihms882129f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bcb/5557715/d22c860823df/nihms882129f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bcb/5557715/8fe502c91b50/nihms882129f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bcb/5557715/a52476171adf/nihms882129f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bcb/5557715/5bd30a1cbb0d/nihms882129f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bcb/5557715/3755d392319a/nihms882129f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bcb/5557715/d22c860823df/nihms882129f5.jpg

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Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):62-69. doi: 10.1016/j.ijrobp.2016.02.018. Epub 2016 Feb 13.
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Initial Report of a Prospective Dosimetric and Clinical Feasibility Trial Demonstrates the Potential of Protons to Increase the Therapeutic Ratio in Breast Cancer Compared With Photons.前瞻性剂量学和临床可行性试验的初步报告表明，与光子相比，质子有潜力提高乳腺癌的治疗比。
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Dosimetric evaluation of photons versus protons in postmastectomy planning for ultrahypofractionated breast radiotherapy.
光子与质子在后乳腺癌根治术后超分割放疗计划中的剂量学评估。
Radiat Oncol. 2022 Jan 29;17(1):20. doi: 10.1186/s13014-022-01992-w.
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Proton Therapy for Breast Cancer: A Consensus Statement From the Particle Therapy Cooperative Group Breast Cancer Subcommittee.质子治疗乳腺癌：粒子治疗合作组乳腺癌子委员会的共识声明。
Int J Radiat Oncol Biol Phys. 2021 Oct 1;111(2):337-359. doi: 10.1016/j.ijrobp.2021.05.110. Epub 2021 May 25.
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Molecular Investigation on a Triple Negative Breast Cancer Xenograft Model Exposed to Proton Beams.质子束照射的三阴性乳腺癌异种移植模型的分子研究。
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